Covid-19 Pubmed Articles

Covid-19 Pubmed Articles
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» The Determinants of the Usability of Telephone-Based Remote Physician Visits
07/08/25 20:00 from Sars-Cov-2 origins
Remote physician visits have been commonly used in Poland since the COVID-19 pandemic. Society's opinions about their usability were rarely assessed systematically. The study's main aim was to assess determinants of the usability of tele...

» Evidence of internal structure validity of the nursing outcome "Mechanical Ventilation Weaning Response: Adult (0412)" for critically ill COVID-19 patients
07/08/25 20:00 from covid-19
CONCLUSIONS: The structure proposed for the NO was shown to be reliable and valid for practice and research to evaluate patients with COVID-19 in the final phase of ventilatory weaning.

» Stoichiometric insights into SARS-CoV-2 spike-ACE2 binding across variants
07/08/25 20:00 from sars-cov-2 spike protein
The SARS-CoV-2 spike protein binds to the angiotensin-converting enzyme 2 (ACE2) receptor to mediate viral entry, with mutations in different variants influencing binding affinity and conformational dynamics. Using large-scale molecular ...

» The Determinants of the Usability of Telephone-Based Remote Physician Visits
07/08/25 20:00 from Coronavirus origins
Remote physician visits have been commonly used in Poland since the COVID-19 pandemic. Society's opinions about their usability were rarely assessed systematically. The study's main aim was to assess determinants of the usability of tele...

» The Determinants of the Usability of Telephone-Based Remote Physician Visits
07/08/25 20:00 from Covid-19 origins
Remote physician visits have been commonly used in Poland since the COVID-19 pandemic. Society's opinions about their usability were rarely assessed systematically. The study's main aim was to assess determinants of the usability of tele...

» The impact of the COVID-19 pandemic on other respiratory viruses in the Haut-Ogooué Province of Gabon
07/08/25 20:00 from coronavirus
CONCLUSIONS: The study reveals a low circulation of respiratory viruses other than SARS-CoV-2 during the period from May 2020 to December 2021. This observation is directly linked to the preponderant circulation of SARS-CoV-2 and the str...

» Targeted Defect-Mapping Microperimetry in Geographic Atrophy: A Sensitive Functional Outcome Measure for Intervention Trials
07/08/25 20:00 from covid-19
CONCLUSIONS: Targeted DMP testing can provide a sensitive functional outcome measure for trials that can capture longitudinal changes as effectively as measuring structural changes in eyes with a small extent of GA. The high structure-fu...

» Therapeutic effect of cardiac rehabilitation on patients with long COVID combined with coronary heart disease: a retrospective study
07/08/25 20:00 from SARS-CoV-2 and Sars-Cov comparisons
CONCLUSION: Patients with long COVID combined with CHD have more severe symptoms, especially for their cardiac function. Cardiac rehabilitation can effectively improve patients' symptoms, and has long-term effects.

» The impact of the COVID-19 pandemic on other respiratory viruses in the Haut-Ogooue Province of Gabon
07/08/25 20:00 from covid-19
CONCLUSIONS: The study reveals a low circulation of respiratory viruses other than SARS-CoV-2 during the period from May 2020 to December 2021. This observation is directly linked to the preponderant circulation of SARS-CoV-2 and the str...

» Mucormycosis and Hearing: A Hospital-Based Study
07/08/25 20:00 from coronavirus
Introduction Mucormycosis, a fungal infection with severe consequences, gained prominence during the coronavirus disease 2019 (COVID-19) pandemic. While significant efforts were made to understand the systemic implications of mucormycosi...

» Stoichiometric insights into SARS-CoV-2 spike-ACE2 binding across variants
07/08/25 20:00 from covid-19
The SARS-CoV-2 spike protein binds to the angiotensin-converting enzyme 2 (ACE2) receptor to mediate viral entry, with mutations in different variants influencing binding affinity and conformational dynamics. Using large-scale molecular ...

» Experiences of community engagement for SARS-COV-2 and COVID-19 community surveillance in a rural and urban population in South Western Uganda
07/08/25 20:00 from coronavirus
CONCLUSION: Successful COVID-19 community surveillance required continuous, active community engagement between the research team, and community stakeholders while maximising previous gains and exploiting existing resources.

» Remote, smart telemonitoring of COVID-19 survivors for early detection of deterioration in cardiac health (the PARTMO study)
07/08/25 20:00 from covid-19
CONCLUSIONS: Considering the risk of developing cardiovascular complications post-COVID-19 infection, regular monitoring, reassessment, and evaluation are recommended as a part of post-COVID-19 management for all patients, including youn...

» Assessing the utility of the COVID-19 epidemic Situations of Concern classification system in guiding operational responses to the pandemic in the WHO African region: retrospective analysis
07/08/25 20:00 from coronavirus
During a public health emergency, early implementation of response activities is crucial for saving lives and protecting livelihoods. The COVID-19 pandemic, declared by the World Health Organization (WHO) on March 11, 2020, posed a globa...

» Impact of the COVID-19 pandemic on seasonal influenza in the WHO Western Pacific Region, 2016-2024
07/08/25 20:00 from covid-19
No abstract

» Anxiety and perceived social support as moderators of cognitive and emotional well-being in populations affected by COVID-19
07/08/25 20:00 from coronavirus
INTRODUCTION: The COVID-19 pandemic has raised significant concerns about its long-term impact on cognitive and emotional functioning. This study explores the role of anxiety and social variables in shaping cognitive performance among in...

» The Impact of Tokenizer Selection in Genomic Language Models
07/08/25 20:00 from SARS-CoV-2 and Sars-Cov comparisons
Genomic language models have recently emerged as a new method to decode, interpret, and generate genetic sequences. Existing genomic language models have utilized various tokenization methods, including character tokenization, overlappin...

» The impact of the COVID-19 pandemic on other respiratory viruses in the Haut-Ogooué Province of Gabon
07/08/25 20:00 from sars-cov-2
CONCLUSIONS: The study reveals a low circulation of respiratory viruses other than SARS-CoV-2 during the period from May 2020 to December 2021. This observation is directly linked to the preponderant circulation of SARS-CoV-2 and the str...

» Microscopy without a microscope? Opportunities and limitations of dental studies in anatomy during the COVID-19 pandemic in Germany
07/08/25 20:00 from covid-19
AIM: Due to the outbreak of the COVID-19 pandemic, the microscopy course as part of the dental medical training in Leipzig, Germany, was transformed from a classroom-only course into a purely digital and later hybrid course with reduced ...

» Antibody repertoire associated with clinically diverse presentations of pediatric SARS-CoV-2 infection
07/08/25 20:00 from covid-19
Pediatric SARS-CoV-2 infection results in clinical presentations ranging from asymptomatic/mild infection to severe pulmonary COVID-19, to Multisystem Inflammatory Syndrome in Children (MIS-C), characterized by hyperinflammation and mult...

» Impact of long COVID-19 on employees of the mining industry in South Africa: a cross-sectional study
07/08/25 20:00 from coronavirus
CONCLUSION: our findings are not generalizable to the entire mining sector due to the limited number of participants who provided data. Additional studies that include a larger sample size are required to obtain more robust estimates of ...

» Access to tuberculosis care in South Africa during the COVID-19 pandemic: A scoping review
07/08/25 20:00 from coronavirus
CONCLUSION: The COVID-19 pandemic has exacerbated pre-existing barriers to TB care in South Africa, highlighting critical gaps in healthcare delivery. This review provides insights into the challenges faced and emphasises the need for re...

» Real-time, multi-pathogen wastewater genomic surveillance with Freyja 2
07/08/25 20:00 from covid-19
Case-based infectious disease surveillance is fundamental to public health, but is resource-intensive, logistically complex, and prone to sampling bias. Wastewater testing and sequencing have increasingly been used for population-scale m...

» Stoichiometric insights into SARS-CoV-2 spike-ACE2 binding across variants
07/08/25 20:00 from sars-cov-2
The SARS-CoV-2 spike protein binds to the angiotensin-converting enzyme 2 (ACE2) receptor to mediate viral entry, with mutations in different variants influencing binding affinity and conformational dynamics. Using large-scale molecular ...

» Conformational Sampling during the Reaction of the SARS-CoV-2 Methyltransferase nsp16
07/08/25 20:00 from coronavirus
The coronavirus 2'-O-methyltransferase nsp16 catalyzes the methylation of the viral RNA cap structure, playing an essential role in viral RNA immune evasion. Unusually, nsp16 forms a heterodimer with a second viral protein, nsp10, which ...

» Mucormycosis and Hearing: A Hospital-Based Study
07/08/25 20:00 from covid-19
Introduction Mucormycosis, a fungal infection with severe consequences, gained prominence during the coronavirus disease 2019 (COVID-19) pandemic. While significant efforts were made to understand the systemic implications of mucormycosi...

» Antibody repertoire associated with clinically diverse presentations of pediatric SARS-CoV-2 infection
07/08/25 20:00 from sars-cov-2
Pediatric SARS-CoV-2 infection results in clinical presentations ranging from asymptomatic/mild infection to severe pulmonary COVID-19, to Multisystem Inflammatory Syndrome in Children (MIS-C), characterized by hyperinflammation and mult...

» Unlocking the Potential of Personal Health Records: A H.E.A.R.T. Framework Evaluation of SATUSEHAT Mobile
07/08/25 20:00 from coronavirus
SATUSEHAT Mobile (SSM), Indonesia's official health application, has evolved from PeduliLindungi during the COVID-19 pandemic into a comprehensive Personal Health Records (PHR) system. Our study evaluated user experiences among 472 respo...

» Evaluating the efficacy of different doses of tocilizumab in treating critically ill COVID-19 patients: a single-center retrospective cohort study
07/08/25 20:00 from covid-19
CONCLUSION: Administering additional doses of TCZ beyond the initial dose was not associated with further reductions in mortality or improvements in other major clinical outcomes in patients with severe or critical COVID-19.

» Evaluating the efficacy of different doses of tocilizumab in treating critically ill COVID-19 patients: a single-center retrospective cohort study
07/08/25 20:00 from sars-cov-2
CONCLUSION: Administering additional doses of TCZ beyond the initial dose was not associated with further reductions in mortality or improvements in other major clinical outcomes in patients with severe or critical COVID-19.

» Editorial: Natural remedies repositioned: advancing drug discovery for infectious diseases
07/08/25 20:00 from covid-19
No abstract

» Experiences of community engagement for SARS-COV-2 and COVID-19 community surveillance in a rural and urban population in South Western Uganda
07/08/25 20:00 from sars-cov-2
CONCLUSION: Successful COVID-19 community surveillance required continuous, active community engagement between the research team, and community stakeholders while maximising previous gains and exploiting existing resources.

» Assessing the utility of the COVID-19 epidemic Situations of Concern classification system in guiding operational responses to the pandemic in the WHO African region: retrospective analysis
07/08/25 20:00 from sars-cov-2
During a public health emergency, early implementation of response activities is crucial for saving lives and protecting livelihoods. The COVID-19 pandemic, declared by the World Health Organization (WHO) on March 11, 2020, posed a globa...

» Experiences of community engagement for SARS-COV-2 and COVID-19 community surveillance in a rural and urban population in South Western Uganda
07/08/25 20:00 from covid-19
CONCLUSION: Successful COVID-19 community surveillance required continuous, active community engagement between the research team, and community stakeholders while maximising previous gains and exploiting existing resources.

» The Determinants of the Usability of Telephone-Based Remote Physician Visits
07/08/25 20:00 from coronavirus
Remote physician visits have been commonly used in Poland since the COVID-19 pandemic. Society's opinions about their usability were rarely assessed systematically. The study's main aim was to assess determinants of the usability of tele...

» The Impact of Nurses' Psychological Well-Being on Organizational Commitment: The Mediating Role of Work Engagement and the Moderating Role of Perceived Organizational Support
07/08/25 20:00 from covid-19
CONCLUSION: Healthcare managers can promote Nurses' Organizational Commitment by employing strategies to enhance their Psychological Well-being, Work Engagement, and Perceived Organizational Support.

» Anxiety and perceived social support as moderators of cognitive and emotional well-being in populations affected by COVID-19
07/08/25 20:00 from sars-cov-2
INTRODUCTION: The COVID-19 pandemic has raised significant concerns about its long-term impact on cognitive and emotional functioning. This study explores the role of anxiety and social variables in shaping cognitive performance among in...

» Impact of the COVID-19 Pandemic on Antibiotic Utilization Trends in Korea: Interrupted Time Series Analysis
07/08/25 20:00 from coronavirus
Since the COVID-19 pandemic began in Korea in January 2020, strict public health measures initially influenced antibiotic utilization, with studies showing mixed results. The emergence of the Omicron variant in November 2021 led to relax...

» Automatic segmentation of chest X-ray images via deep-improved various U-Net techniques
07/08/25 20:00 from covid-19
CONCLUSION: The U-Net9 architecture offers a superior solution for CXR image segmentation. It combines high segmentation accuracy with computational practicality, making it suitable for real-world applications. Its implementation can sup...

» COVID-19 Pandemic-Related Disruptions in Routine Cirrhosis Care and Associated Clinical Outcomes among San Francisco Bay Area Veterans
07/08/25 20:00 from sars-cov-2
CONCLUSION: The pandemic significantly disrupted cirrhosis care among Bay Area Veterans, potentially resulting in "health debt" that may affect outcomes in coming years. Targeted interventions should re-engage patients, addressing these ...

» Applying Text Mining to Identify the Need for Long-Term Care Facilities to Introduce Smart Technology
07/08/25 20:00 from coronavirus
After the COVID-19 pandemic, there has been a rapid shortage of caregiving personnel, and the use of medical technology to alleviate caregiving pressures has become an emerging trend. This study aims to understand the demand for the intr...

» Therapeutic effect of cardiac rehabilitation on patients with long COVID combined with coronary heart disease: a retrospective study
07/08/25 20:00 from sars-cov-2
CONCLUSION: Patients with long COVID combined with CHD have more severe symptoms, especially for their cardiac function. Cardiac rehabilitation can effectively improve patients' symptoms, and has long-term effects.

» Physicians' Perspectives on the Integration of Clinical Decision Support Systems in COVID-19 Management
07/08/25 20:00 from coronavirus
This study explores Chinese physicians' perspectives on the integration of clinical decision support (CDS) into electronic health records for COVID-19 management. A total of 148 physicians were surveyed, of whom 98.6% (146/148) completed...

» TCR2HLA: calibrated inference of HLA genotypes from TCR repertoires enables identification of immunologically relevant metaclonotypes
07/08/25 20:00 from sars-cov-2
T cell receptors (TCRs) recognize peptides presented by polymorphic human leukocyte antigen (HLA) molecules, but HLA genotype data are often missing from TCR repertoire sequencing studies. To address this, we developed TCR2HLA, an open-s...

» Temporal Evolution of Public Health Sentiment: A Longitudinal Analysis
07/08/25 20:00 from coronavirus
This study advances our understanding of public health crisis communication by conducting a longitudinal analysis. As COVID-19 has been the largest public health crisis to date, we performed sentiment analysis on it. While previous resea...

» The Impact of Tokenizer Selection in Genomic Language Models
07/08/25 20:00 from sars-cov-2
Genomic language models have recently emerged as a new method to decode, interpret, and generate genetic sequences. Existing genomic language models have utilized various tokenization methods, including character tokenization, overlappin...

» Development and Validation of Statements on Nursing Digital Capabilities for Climate-Resilient Healtcare Systems
07/08/25 20:00 from coronavirus
Building on our previous research on nurses' adoption and use of digital technology during the COVID-19 pandemic and guided by the Health Emergency and Disaster Risk Management framework, we initiated a study to develop recommendations f...

» Characterization of antiviral compounds using Bio-Layer Interferometry
07/08/25 20:00 from sars-cov-2
Small molecule-protein interactions underpin many biological functions and play an integral role in the treatment and prevention of several human diseases. These interactions can be key to understanding the mechanism of action of these c...

» Omicron Subvariants Infection Kinetics and Nirmatrelvir Efficacy in Transgenic K18-hACE2 Mice
07/08/25 20:00 from sars-cov-2
The persistent evolution of SARS-CoV-2 has led to the emergence of antigenically distinct Omicron subvariants exhibiting increased transmissibility, immune evasion, and altered pathogenicity. Among these, recent subvariants like JN.1, KP...

» Impact of long COVID-19 on employees of the mining industry in South Africa: a cross-sectional study
07/08/25 20:00 from sars-cov-2
CONCLUSION: our findings are not generalizable to the entire mining sector due to the limited number of participants who provided data. Additional studies that include a larger sample size are required to obtain more robust estimates of ...

» Access to tuberculosis care in South Africa during the COVID-19 pandemic: A scoping review
07/08/25 20:00 from sars-cov-2
CONCLUSION: The COVID-19 pandemic has exacerbated pre-existing barriers to TB care in South Africa, highlighting critical gaps in healthcare delivery. This review provides insights into the challenges faced and emphasises the need for re...

» Idiopathic Retroperitoneal Hematoma Associated With Anticoagulation in a Patient With Moderate COVID-19 Pneumonia: A Case Report
06/08/25 20:00 from covid-19
We report a case of idiopathic retroperitoneal hematoma in an 82-year-old man with moderate COVID-19 pneumonia receiving prophylactic anticoagulation therapy. The patient was initially treated with remdesivir, dexamethasone, and subcutan...

» Mapping learning preferences in nursing education: A cross-sectional study among generation Z students
06/08/25 20:00 from covid-19
CONCLUSION: In conclusion, understanding and addressing diverse learning styles is essential for policymakers and educators to foster effective education systems to identify a responsive approach to learning style to improve educational ...

» Factors influencing stress and coping strategies among critical care nurses: A cross-sectional analysis
06/08/25 20:00 from covid-19
CONCLUSIONS: It is recommended that extra effort should be given to CCNs' ability to adapt to stressful situations. It is possible to improve the retention rates of new nurses by improving their ability to accommodate and by assisting th...

» Occupational stressors experienced by pediatric residents during COVID-19 pandemic: A mixed-methods sequential explanatory study
06/08/25 20:00 from covid-19
CONCLUSION: Given the prominent role of residents in the healthcare system, paying attention to their occupational stress is essential. Therefore, all health policymakers are recommended to alleviate medical residents' occupational stres...

» Nurse-led social media-based education in diabetic patients: Effects on COVID-19 fear and self-care - A 6-month follow-up trial
06/08/25 20:00 from covid-19
CONCLUSION: Social media-based nurse-led education effectively reduces COVID-19-associated fear and improves self-care in diabetic patients, with benefits sustained for up to six months. This approach is recommended for accessible, scala...

» Developing and assessing the psychometric properties of the faculty members' attitudes toward e-learning courses questionnaire
06/08/25 20:00 from covid-19
CONCLUSIONS: We developed a valid and reliable questionnaire to assess the faculty members' attitudes toward e-learning. Iranian higher education institutions as well as TUMS can utilize it as a valid and reliable tool to evaluate facult...

» A Comprehensive Review of Theaflavins: Physiological Activities, Synthesis Techniques, and Future Challenges
06/08/25 20:00 from covid-19
Theaflavins (TFs), which are polyphenolic compounds characterized by a benzotropolone structure, serve as the primary quality and health-promoting components in black tea. Recent investigations have disclosed various health advantages li...

» Neuropsychiatric symptoms cluster as primary drivers of Long COVID complexity: a South Texas retrospective cohort study
06/08/25 20:00 from covid-19
Long COVID, previously known as Post-Acute Sequelae of SARS-CoV-2 (PASC), refers to prolonged symptoms or diagnosable conditions following COVID-19 infection. The neuropsychiatric profile of Long COVID patients remains ambiguous. This st...

» Occupational stressors experienced by pediatric residents during COVID-19 pandemic: A mixed-methods sequential explanatory study
06/08/25 20:00 from coronavirus
CONCLUSION: Given the prominent role of residents in the healthcare system, paying attention to their occupational stress is essential. Therefore, all health policymakers are recommended to alleviate medical residents' occupational stres...

» From digital traces to public vaccination behaviors: leveraging large language models for big data classification
06/08/25 20:00 from covid-19
INTRODUCTION: The current study leverages large language models (LLMs) to capture health behaviors expressed in social media posts, focusing on COVID-19 vaccine-related content from 2020 to 2021.

» Pharmacodynamics, pharmacokinetics, interactions with other drugs, toxicity and clinical effectiveness of proton pump inhibitors
06/08/25 20:00 from covid-19
The document comprehensively reviews proton pump inhibitors (PPIs), focusing on their pharmacodynamics, pharmacokinetics, drug interactions, toxicity, and clinical efficacy. PPIs irreversibly inhibit the H+/K+-ATPase enzyme in gastric pa...

» Hotels as quarantine facilities with airborne virus controls
06/08/25 20:00 from covid-19
During the COVID-19 pandemic, hotels were converted into quarantine facilities, often lacking adequate air-cleaning infrastructure. This study aimed to design effective air-cleaning strategies for controlling viral aerosol transmission, ...

» PROS1 (Cys228Tyr) missense mutation associated with mesenteric and pulmonary venous thromboembolism during the COVID-19 pandemic: a case report
06/08/25 20:00 from covid-19
BACKGROUND: Venous thromboembolism (VTE) is influenced by both genetic and acquired risk factors, with protein S (PS) deficiency recognized as a well-established inherited thrombophilia. Introduction: We report the case of a 32-year-old ...

» A Comprehensive Review of Theaflavins: Physiological Activities, Synthesis Techniques, and Future Challenges
06/08/25 20:00 from coronavirus
Theaflavins (TFs), which are polyphenolic compounds characterized by a benzotropolone structure, serve as the primary quality and health-promoting components in black tea. Recent investigations have disclosed various health advantages li...

» MACRO SOLUTIONS TO A MICRO PROBLEM: DRUG-RESISTANT PNEUMOCOCCAL PNEUMONIA
06/08/25 20:00 from covid-19
Even before the COVID-19 pandemic, acute respiratory infections represented one of the most common reasons for patients to seek urgent medical care. S. pneumoniae is one of the most frequent bacterial causes of acute respiratory infectio...

» Proceedings from the Fourth Mesoamerican Symposium "Dr. Roberto Navarro López" on Emerging Zoonotic Disease and Arboviruses: Commenting Insights and Research Findings
06/08/25 20:00 from coronavirus
Zoonotic pathogens such as arboviruses, arenaviruses, filoviruses, coronaviruses, highly pathogenic Avian Influenza A (H5N1) viruses, vesiculoviruses, and many others are emerging and reemerging worldwide, jeopardizing global veterinary ...

» Trends in Fine Particulate Matter and Source Contributions over the Last Decade in Central Los Angeles (2014-2024): Policy-Driven Declines, COVID-19 Disruptions, and Wildfires
06/08/25 20:00 from covid-19
This study analyzed speciated PM(2.5) data (2014-2024) from the Chemical Speciation Network in central Los Angeles and used positive matrix factorization (PMF) to identify and apportion sources, and quantified changes in their contributi...

» Socioeconomic and Demographic Factors Associated With Mortality Before and During the COVID-19 Pandemic: An Analysis of 28 European Countries
06/08/25 20:00 from coronavirus
CONCLUSION: The pandemic highlighted socioeconomic gradients in mortality. These results call for policymakers to prepare for future shocks, ensuring equal access to adequate care.

» Socioeconomic and Demographic Factors Associated With Mortality Before and During the COVID-19 Pandemic: An Analysis of 28 European Countries
06/08/25 20:00 from covid-19
CONCLUSION: The pandemic highlighted socioeconomic gradients in mortality. These results call for policymakers to prepare for future shocks, ensuring equal access to adequate care.

» How did Canadian national team athletes manage the COVID-19 pandemic? Athlete, coach, and support staff perspectives to guide future responses to major stressors
06/08/25 20:00 from coronavirus
As we move beyond the pandemic and the lockdowns it imposed on elite athletes, there remains much to learn from how they adapted to this unprecedented crisis. Given the significant impact on their mental health-and the likelihood that th...

» Dominance of the GI-19 genotype and genomic characterization of the S1 gene in avian infectious bronchitis virus from 2020 to 2024
06/08/25 20:00 from coronavirus
The continuous emergence of avian infectious bronchitis virus (IBV) variants poses a critical threat to poultry health and productivity in China. In this study, we conducted comprehensive genetic and antigenic analyses of IBV strains iso...

» Exploring the Relation between Contextual Social Determinants of Health and COVID-19 Occurrence and Hospitalization
06/08/25 20:00 from coronavirus
It is prudent to take a unified approach to exploring how contextual social determinants of health (SDoH) relate to COVID-19 occurrence and outcomes. Poor geographically represented data and a small number of contextual SDoH examined in ...

» Temporal Trends in Pulmonary Embolism Mortality Associated with COVID-19 in the United States: A 5-Year Retrospective Analysis
06/08/25 20:00 from coronavirus
Coronavirus disease 2019 (COVID-19) has been strongly associated with thrombotic complications, particularly pulmonary embolism (PE). This study aims to analyze the real-world impact of COVID-19 on PE-related mortality in the United Stat...

» Insights from the front line: uplifting stories of the COVID-19 pandemic through the eyes of the public health workforce in Iowa
06/08/25 20:00 from coronavirus
INTRODUCTION: SARS-CoV-2 was declared a pandemic in March 2020. Studies have characterized some of the negative impact of the pandemic on public health workers (PHW), but few have explored the strength and coping strategies used. Our stu...

» Rapid public health genomics capacity building during the COVID-19 Delta crisis driven by a transnational private, public, and social alliance
06/08/25 20:00 from coronavirus
When the COVID-19's Delta variant spread globally during late 2020, Public Health Genomics (PHG) capabilities were missing in several cities, significantly impairing the ability of policymakers and public health systems to rapidly identi...

» Evolution of the psychological repercussions of the COVID-19 pandemic on hemodialysis patients and caregivers between April 2020 and April 2022
06/08/25 20:00 from coronavirus
CONCLUSION: By April 2022, in France, hemodialysis caregivers' and patients' health crisis-related stress and anxiety levels had decreased compared with April 2020. Positive thinking coping strategies should be promoted among patients an...

» A modular polymer platform for efficient mRNA delivery in cancer immunotherapy
06/08/25 20:00 from coronavirus
The use of mRNA for prophylactic and therapeutic applications, such as treating coronavirus and cancer, has garnered significant attention. However, owing to the inherent labile nature of mRNA, it requires robust delivery platforms to en...

» Coproducing COVID-19 Health Information Resources: A Participatory Study With Older Adults From Minoritised Ethnic Communities in the UK
06/08/25 20:00 from coronavirus
CONCLUSION: We adopted an inclusive and participatory approach to formulating culturally relevant information resources on COVID-19. The coproduction process, findings, and reflections from this study may be useful in informing future pu...

» Sickness absence due to mental disorders among young adults: A register-based comparison of Finnish and Swedish speakers in Finland
06/08/25 20:00 from coronavirus
CONCLUSIONS: Before the coronavirus pandemic, the use of sickness allowance due to mental health problems increased and became more similar for Finnish- and Swedish-speaking young adults.

» When the World Pivots: Changes in Infant Negative Affect Trajectories Following the Onset of the COVID-19 Pandemic
06/08/25 20:00 from coronavirus
Research on the COVID-19 pandemic's effect on infant emotional development has produced mixed results, often limited by methodological constraints, such as not having access to data prior to and after pandemic onset. This study helps ove...

» A Comprehensive Review of Theaflavins: Physiological Activities, Synthesis Techniques, and Future Challenges
06/08/25 20:00 from sars-cov-2
Theaflavins (TFs), which are polyphenolic compounds characterized by a benzotropolone structure, serve as the primary quality and health-promoting components in black tea. Recent investigations have disclosed various health advantages li...

» Neuropsychiatric symptoms cluster as primary drivers of Long COVID complexity: a South Texas retrospective cohort study
06/08/25 20:00 from sars-cov-2
Long COVID, previously known as Post-Acute Sequelae of SARS-CoV-2 (PASC), refers to prolonged symptoms or diagnosable conditions following COVID-19 infection. The neuropsychiatric profile of Long COVID patients remains ambiguous. This st...

» Socioeconomic and Demographic Factors Associated With Mortality Before and During the COVID-19 Pandemic: An Analysis of 28 European Countries
06/08/25 20:00 from sars-cov-2
CONCLUSION: The pandemic highlighted socioeconomic gradients in mortality. These results call for policymakers to prepare for future shocks, ensuring equal access to adequate care.

» Exploring the Relation between Contextual Social Determinants of Health and COVID-19 Occurrence and Hospitalization
06/08/25 20:00 from sars-cov-2
It is prudent to take a unified approach to exploring how contextual social determinants of health (SDoH) relate to COVID-19 occurrence and outcomes. Poor geographically represented data and a small number of contextual SDoH examined in ...

» Insights from the front line: uplifting stories of the COVID-19 pandemic through the eyes of the public health workforce in Iowa
06/08/25 20:00 from sars-cov-2
INTRODUCTION: SARS-CoV-2 was declared a pandemic in March 2020. Studies have characterized some of the negative impact of the pandemic on public health workers (PHW), but few have explored the strength and coping strategies used. Our stu...

» Rapid public health genomics capacity building during the COVID-19 Delta crisis driven by a transnational private, public, and social alliance
06/08/25 20:00 from sars-cov-2
When the COVID-19's Delta variant spread globally during late 2020, Public Health Genomics (PHG) capabilities were missing in several cities, significantly impairing the ability of policymakers and public health systems to rapidly identi...

» Spatially Layered Dual-Porous Nanohybrids Enabling a Colorimetric-Fluorometric-Catalytic Continuous Gradient Signal Response for High-Performance Immunochromatographic Diagnosis
06/08/25 20:00 from sars-cov-2
Achieving high sensitivity, a broad linear range, and accurate quantification in lateral flow immunoassays (LFIAs) remains a significant challenge, particularly due to limitations in signal mode integration. Herein, we report a novel mul...

» Evolution of the psychological repercussions of the COVID-19 pandemic on hemodialysis patients and caregivers between April 2020 and April 2022
06/08/25 20:00 from sars-cov-2
CONCLUSION: By April 2022, in France, hemodialysis caregivers' and patients' health crisis-related stress and anxiety levels had decreased compared with April 2020. Positive thinking coping strategies should be promoted among patients an...

» Coproducing COVID-19 Health Information Resources: A Participatory Study With Older Adults From Minoritised Ethnic Communities in the UK
06/08/25 20:00 from sars-cov-2
CONCLUSION: We adopted an inclusive and participatory approach to formulating culturally relevant information resources on COVID-19. The coproduction process, findings, and reflections from this study may be useful in informing future pu...

» When the World Pivots: Changes in Infant Negative Affect Trajectories Following the Onset of the COVID-19 Pandemic
06/08/25 20:00 from sars-cov-2
Research on the COVID-19 pandemic's effect on infant emotional development has produced mixed results, often limited by methodological constraints, such as not having access to data prior to and after pandemic onset. This study helps ove...

» Improving the accuracy of emergency department clinicians in detecting SARS-COV-2 on chest X-rays using a bespoke virtual training platform
06/08/25 20:00 from sars-cov-2
CONCLUSION: ED clinicians show moderate baseline accuracy in the identification of SARS-CoV-2 related changes on CXR. Accuracy and speed can be improved by online training.

» A portrait of online gambling: a look at a transformation amid a pandemic
06/08/25 20:00 from sars-cov-2
CONCLUSION: The COVID-19 pandemic clearly revealed a significant increase in online gambling practices when changes in the gambling landscape and in daily life occurred due to the health crisis. This calls for a greater attention to the ...

» Lessons for the Next Global Health Crisis: A Qualitative Systematic Review of Women's Experiences of the Perinatal Period During the COVID-19 Pandemic in Australia
06/08/25 20:00 from sars-cov-2
CONCLUSIONS: Three lessons were highlighted. First, women need accurate, accessible health information to make informed decisions. Second, policies should support family bonding and social connections during government restrictions. Fina...

» "We were on lockdown for pretty much my entire pregnancy": a qualitative study of pregnancy care in prisons and jails during the COVID-19 pandemic
06/08/25 20:00 from sars-cov-2
CONCLUSION: The COVID-19 pandemic exacerbated existing disparities and inequitable access to perinatal care for incarcerated people. We conclude with a series of policy and practice recommendations that carceral facilities may implement ...

» AI-derived CT biomarker score for robust COVID-19 mortality prediction across multiple waves and regions using machine learning
06/08/25 20:00 from sars-cov-2
This study aimed to develop a simple, interpretable model using routinely available data for predicting COVID-19 mortality at admission, addressing limitations of complex models, and to provide a statistically robust framework for contro...

» Tracing SARS-CoV-2 clusters across local scales using genomic data
06/08/25 20:00 from Sars-Cov-2 origins
A quantitative understanding of local transmission dynamics is essential for designing effective prevention strategies. In this study, we developed a computational workflow to identify viral introductions and trace locally circulating cl...

» A luminescent attenuated SARS-CoV-2 for the identification and validation of drug-resistant mutants
06/08/25 20:00 from Sars-Cov-2 origins
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants has necessitated a continuous updating of vaccines. In contrast, antivirals remained effective as they target conserved viral proteins that are essent...

» Tracing SARS-CoV-2 clusters across local scales using genomic data
06/08/25 20:00 from Coronavirus origins
A quantitative understanding of local transmission dynamics is essential for designing effective prevention strategies. In this study, we developed a computational workflow to identify viral introductions and trace locally circulating cl...

» Characterization of private mutations in the spike protein of SARS-CoV-2 correlates with viral prevalence
06/08/25 20:00 from sars-cov-2 spike protein
CONCLUSIONS: Continuous monitoring and functional analysis of SARS-CoV-2 private mutations can be an effective approach for explaining patterns of viral prevalence. This has significant implications for the timely formulation of preventi...

» A luminescent attenuated SARS-CoV-2 for the identification and validation of drug-resistant mutants
06/08/25 20:00 from Coronavirus origins
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants has necessitated a continuous updating of vaccines. In contrast, antivirals remained effective as they target conserved viral proteins that are essent...

» An unexpected insight into the cause of olfactory dysfunction: fibrillogenesis of odorant-binding proteins
06/08/25 20:00 from Covid-19 origins
Olfactory dysfunction is a common complication of serious pathologies, including neurodegenerative disorders, bacterial and viral infections, including COVID-19, and others. Despite the widespread prevalence of olfactory disorders, the p...

» Tracing SARS-CoV-2 clusters across local scales using genomic data
06/08/25 20:00 from Covid-19 origins
A quantitative understanding of local transmission dynamics is essential for designing effective prevention strategies. In this study, we developed a computational workflow to identify viral introductions and trace locally circulating cl...

» A luminescent attenuated SARS-CoV-2 for the identification and validation of drug-resistant mutants
06/08/25 20:00 from Covid-19 origins
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants has necessitated a continuous updating of vaccines. In contrast, antivirals remained effective as they target conserved viral proteins that are essent...

» SpikeID: Rapid and unbiased identification of SARS-CoV-2 variants by spike sequencing
06/08/25 20:00 from SARS-CoV-2 and Sars-Cov comparisons
CONCLUSIONS: We demonstrate the utility and scalability of the SpikeID assay during the emergence and subsequent surge of Omicron and Omicron-derived lineages in New York City, and show that our approach enables cost-effective, reliable,...

» Health-related quality of life and QALY loss under COVID-19 lockdown: The case of Spain
06/08/25 20:00 from SARS-CoV-2 and Sars-Cov comparisons
CONCLUSIONS: A population under a lockdown situation reported higher rates of anxiety/depression problems than in a regular situation. On a country-wide scope, this may lead to a substantial loss in terms of QALYs, especially over longer...

» Amyloidogenic SARS-CoV-2 Spike Protein-Derived Peptides Form Oligomers and Selectively Damage Lipid Membranes
05/08/25 20:00 from sars-cov-2 spike protein
Several peptides derived from the SARS-CoV-2 spike protein (S-protein) are amyloidogenic, suggesting a potential role in COVID-19 disease-associated pathogenesis. Many disease-related amyloids form a variety of intermediate oligomeric ag...

» Amyloidogenic SARS-CoV-2 Spike Protein-Derived Peptides Form Oligomers and Selectively Damage Lipid Membranes
05/08/25 20:00 from sars-cov-2
Several peptides derived from the SARS-CoV-2 spike protein (S-protein) are amyloidogenic, suggesting a potential role in COVID-19 disease-associated pathogenesis. Many disease-related amyloids form a variety of intermediate oligomeric ag...

» Changes in Reimbursed Acupuncture Therapy Amidst the COVID-19 Pandemic: A Cross-Sectional Analysis
05/08/25 20:00 from sars-cov-2
CONCLUSIONS: The COVID-19 pandemic had a disproportionate impact on acupuncture therapy, which may be driven by a reduction in acupuncturists who billed insurance. Future research should assess the long-term impact of COVID-19 on acupunc...

» Coronavirus protein interaction mapping in bat and human cells identifies molecular and genetic switches for immune evasion and replication
05/08/25 20:00 from Sars-Cov-2 origins
Coronaviruses, including SARS-CoV-2, can cause severe disease in humans, whereas reservoir hosts like Rhinolophus bats remain asymptomatic. To investigate how host-specific protein-protein interactions (PPIs) influence infection, we gene...

» Coronavirus protein interaction mapping in bat and human cells identifies molecular and genetic switches for immune evasion and replication
05/08/25 20:00 from sars-cov-2
Coronaviruses, including SARS-CoV-2, can cause severe disease in humans, whereas reservoir hosts like Rhinolophus bats remain asymptomatic. To investigate how host-specific protein-protein interactions (PPIs) influence infection, we gene...

» A Structure-Based Computational Pipeline for Broad-Spectrum Antiviral Discovery
05/08/25 20:00 from sars-cov-2
The rapid emergence of viruses with pandemic potential continues to pose a threat to public health worldwide. With the typical drug discovery pipeline taking an average of 5-10 years to reach clinical readiness, there is an urgent need f...

» Coronavirus protein interaction mapping in bat and human cells identifies molecular and genetic switches for immune evasion and replication
05/08/25 20:00 from Coronavirus origins
Coronaviruses, including SARS-CoV-2, can cause severe disease in humans, whereas reservoir hosts like Rhinolophus bats remain asymptomatic. To investigate how host-specific protein-protein interactions (PPIs) influence infection, we gene...

» Cooperativity and Communication between the Active Sites of the Dimeric SARS-CoV-2 Main Protease
05/08/25 20:00 from sars-cov-2
The coronaviral main protease (M ^(pro) ) is essential for the replication of the virus, and has been the subject of various biochemical, structural and enzymatic studies, as well as a drug target against SARS-CoV-2 infections. SARS-CoV-...

» Inhibition of coronaviral exonuclease activity by TRIM-mediated SUMOylation
05/08/25 20:00 from sars-cov-2
Members of the TRIM E3 ligase family are effectors of the host innate or intrinsic defense against various viruses; however, how specific TRIM proteins antagonize coronavirus infection is still largely elusive. Through an RNAi screen tar...

» Decreases in chimpanzee respiratory disease signs and enteric viral quantity following implementation of anthroponotic disease prevention protocols at a long-term research site
05/08/25 20:00 from Covid-19 origins
Diseases transmitted from humans (i.e., anthroponotic diseases or anthroponoses) are among the leading causes of ill health and mortality for wild chimpanzees (Pan troglodytes). Although various health and hygiene protocols have been pro...

» Long-term impact of oral cladribine on humoral immunity in multiple sclerosis
05/08/25 20:00 from sars-cov-2
CONCLUSION: These long-term data suggest that CLAD treatment does not impact preexisting humoral immunity or antibody production toward novel antigens. Our results support the positive long-term safety profile of the drug.

» Understanding COVID-19 booster information seeking in a collectivist context: the roles of social expectations, trust in experts, and uncertainty
05/08/25 20:00 from sars-cov-2
CONCLUSION: Findings highlight the need to incorporate social norms, trust relationships, and uncertainty management into public health education campaigns to support vaccine promotion. This study offers empirical evidence for designing ...

» Coronavirus protein interaction mapping in bat and human cells identifies molecular and genetic switches for immune evasion and replication
05/08/25 20:00 from Covid-19 origins
Coronaviruses, including SARS-CoV-2, can cause severe disease in humans, whereas reservoir hosts like Rhinolophus bats remain asymptomatic. To investigate how host-specific protein-protein interactions (PPIs) influence infection, we gene...

» Amyloidogenic SARS-CoV-2 Spike Protein-Derived Peptides Form Oligomers and Selectively Damage Lipid Membranes
05/08/25 20:00 from covid-19
Several peptides derived from the SARS-CoV-2 spike protein (S-protein) are amyloidogenic, suggesting a potential role in COVID-19 disease-associated pathogenesis. Many disease-related amyloids form a variety of intermediate oligomeric ag...

» SARS-CoV-2 ORF7 subgenomic RNA and Host IFN-beta Expression in COVID-19 Hospitalized Patients with Different Prognosis
05/08/25 20:00 from sars-cov-2
The worldwide spread of COVID-19, triggered by SARS-CoV-2, has highlighted how viral accessory proteins contribute significantly to bypassing host immune defenses and increasing illness severity. This study investigates the relationship ...

» Comparison of Infection-Induced SARS-CoV-2 Seroprevalence Across Large-Scale Residual Samples From Blood Donors, Commercial Laboratories, and Health Checkups in Japan, 2023
05/08/25 20:00 from sars-cov-2
We compared severe acute respiratory syndrome coronavirus 2 nucleocapsid antibody seroprevalence using 3 types of residual blood samples simultaneously collected in November-December 2023 from blood donors, commercial laboratories, and h...

» Changes in Reimbursed Acupuncture Therapy Amidst the COVID-19 Pandemic: A Cross-Sectional Analysis
05/08/25 20:00 from covid-19
CONCLUSIONS: The COVID-19 pandemic had a disproportionate impact on acupuncture therapy, which may be driven by a reduction in acupuncturists who billed insurance. Future research should assess the long-term impact of COVID-19 on acupunc...

» Decreases in chimpanzee respiratory disease signs and enteric viral quantity following implementation of anthroponotic disease prevention protocols at a long-term research site
05/08/25 20:00 from covid-19
Diseases transmitted from humans (i.e., anthroponotic diseases or anthroponoses) are among the leading causes of ill health and mortality for wild chimpanzees (Pan troglodytes). Although various health and hygiene protocols have been pro...

» A short questionnaire to assess changes in lifestyle-related behavior upon stressful events: translation, cultural adaptation, and validation study for the Portuguese language
05/08/25 20:00 from covid-19
The COVID-19 pandemic impacted considerably university students' health and well-being, justifying the development and use of validated measuring tools to analyse and assess mental/physical health, and well-being throughout consecutive c...

» Artificial intelligence algorithms based approach in evaluating COVID-19 patients and management
05/08/25 20:00 from sars-cov-2
CONCLUSIONS: AI-based chest CT analysis plays a crucial role in assessing patients with COVID-19 pneumonia. When combined with inflammatory markers, it provides a reliable and objective method for evaluating COVID-19 pneumonia, enhancing...

» Molecular insights into the bidirectional link between anxiety and COVID-19: a combined clinical and bioinformatics approach
05/08/25 20:00 from covid-19
CONCLUSION: These results provide molecular-level evidence for a bidirectional association between COVID-19 and anxiety, potentially mediated by dysregulated inflammatory cytokines and other secreted proteins. Furthermore, impaired cogni...

» The healthcare burden imposed by children with gastroparesis and the shift imposed by COVID-19
05/08/25 20:00 from covid-19
CONCLUSION: This PHIS database study confirms an upward trend in the annual healthcare utilization by children admitted with GP, resulting in an upward trend in the total economic burden on children's hospitals emphasized by the COVID-19...

» Smart working and active mobility for reducing CO2 emissions from the home-to-work commute: the results of the Climactions project
05/08/25 20:00 from sars-cov-2
CONCLUSIONS: in Italy, road transport accounts for approximately 25% of the total CO2 emissions. The lockdown provided a natural scenario for reducing emissions in urban areas, and the implementation of smart working was associated with ...

» Immunothrombosis and plasma fibrinolytic function for pediatric COVID-19: a secondary analysis from the COVAC-TP trial
05/08/25 20:00 from covid-19
The relationship between fibrinolysis, inflammation, and prothrombotic risk among children hospitalized for coronavirus disease 2019 (COVID-19)-related illness is ill defined. To investigate the association between plasma fibrinolytic ca...

» Modulating functional allostery of the host-cell receptor protein hACE2 to inhibit viral entry of SARS-CoV-2
05/08/25 20:00 from sars-cov-2
The emergence of new SARS-CoV-2 Omicron sub-variants with faster transmission has necessitated accelerated scientific efforts to confront a possible health emergency. Conventional anti-CoV strategies targeting viral proteins often fail d...

» Adenovirus-Based Single-Dose Vaccines for SARS-CoV-2: A Review
05/08/25 20:00 from sars-cov-2
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak has many unexpected implications, but the scientific community remains optimistic about overcoming these obstacles. Adenoviruses (Ad) are considered the most suita...

» Association of high gamma' fibrinogen levels with adverse events in patients with COVID-19
05/08/25 20:00 from covid-19
No abstract

» Comparison of Infection-Induced SARS-CoV-2 Seroprevalence Across Large-Scale Residual Samples From Blood Donors, Commercial Laboratories, and Health Checkups in Japan, 2023
05/08/25 20:00 from SARS-CoV-2 and Sars-Cov comparisons
We compared severe acute respiratory syndrome coronavirus 2 nucleocapsid antibody seroprevalence using 3 types of residual blood samples simultaneously collected in November-December 2023 from blood donors, commercial laboratories, and h...

» Deployed in Disaster: Perspectives of Personnel Deployed in Ontario Long-Term Care During the Pandemic
05/08/25 20:00 from sars-cov-2
AIM: The aim of the study is to explore the experience and perspectives of healthcare personnel deployed from the hospitals and military into long-term care (LTC) in Ontario during the pandemic.

» Rapid generation of HCoV-229E and HCoV-OC43 reporter viruses and replicons for antiviral research
05/08/25 20:00 from covid-19
INTRODUCTION: The large size of coronavirus genome, along with the instability of certain genomic sequences, makes the construction of reverse genetics for coronaviruses particularly challenging. The rapid development and application of ...

» Willingness to Use Telemedicine Among Patients With Chronic Diseases in Northern Jordan: A Qualitative Study
05/08/25 20:00 from covid-19
CONCLUSION: Patients' perspectives on telemedicine reveal key opportunities to integrate this technology into chronic disease care in Jordan. Continued care is essential for managing chronic diseases, and telemedicine could play a crucia...

» Coronavirus protein interaction mapping in bat and human cells identifies molecular and genetic switches for immune evasion and replication
05/08/25 20:00 from covid-19
Coronaviruses, including SARS-CoV-2, can cause severe disease in humans, whereas reservoir hosts like Rhinolophus bats remain asymptomatic. To investigate how host-specific protein-protein interactions (PPIs) influence infection, we gene...

» Standardizing a Protocol for Streamlined Synthesis and Characterization of Lipid Nanoparticles to Enable Preclinical Research and Education
05/08/25 20:00 from covid-19
Lipid nanoparticles (LNPs) have revolutionized nucleic acid delivery, enabled the first FDA-approved RNAi therapy (Onpattro), and accelerated the development of mRNA vaccines during the COVID-19 pandemic. The success of LNP-based vaccine...

» A Structure-Based Computational Pipeline for Broad-Spectrum Antiviral Discovery
05/08/25 20:00 from covid-19
The rapid emergence of viruses with pandemic potential continues to pose a threat to public health worldwide. With the typical drug discovery pipeline taking an average of 5-10 years to reach clinical readiness, there is an urgent need f...

» Cooperativity and Communication between the Active Sites of the Dimeric SARS-CoV-2 Main Protease
05/08/25 20:00 from covid-19
The coronaviral main protease (M ^(pro) ) is essential for the replication of the virus, and has been the subject of various biochemical, structural and enzymatic studies, as well as a drug target against SARS-CoV-2 infections. SARS-CoV-...

» Inhibition of coronaviral exonuclease activity by TRIM-mediated SUMOylation
05/08/25 20:00 from covid-19
Members of the TRIM E3 ligase family are effectors of the host innate or intrinsic defense against various viruses; however, how specific TRIM proteins antagonize coronavirus infection is still largely elusive. Through an RNAi screen tar...

» Changes in Reimbursed Acupuncture Therapy Amidst the COVID-19 Pandemic: A Cross-Sectional Analysis
05/08/25 20:00 from coronavirus
CONCLUSIONS: The COVID-19 pandemic had a disproportionate impact on acupuncture therapy, which may be driven by a reduction in acupuncturists who billed insurance. Future research should assess the long-term impact of COVID-19 on acupunc...

» Immunothrombosis and plasma fibrinolytic function for pediatric COVID-19: a secondary analysis from the COVAC-TP trial
05/08/25 20:00 from coronavirus
The relationship between fibrinolysis, inflammation, and prothrombotic risk among children hospitalized for coronavirus disease 2019 (COVID-19)-related illness is ill defined. To investigate the association between plasma fibrinolytic ca...

» Rapid generation of HCoV-229E and HCoV-OC43 reporter viruses and replicons for antiviral research
05/08/25 20:00 from coronavirus
INTRODUCTION: The large size of coronavirus genome, along with the instability of certain genomic sequences, makes the construction of reverse genetics for coronaviruses particularly challenging. The rapid development and application of ...

» Coronavirus protein interaction mapping in bat and human cells identifies molecular and genetic switches for immune evasion and replication
05/08/25 20:00 from coronavirus
Coronaviruses, including SARS-CoV-2, can cause severe disease in humans, whereas reservoir hosts like Rhinolophus bats remain asymptomatic. To investigate how host-specific protein-protein interactions (PPIs) influence infection, we gene...

» A Structure-Based Computational Pipeline for Broad-Spectrum Antiviral Discovery
05/08/25 20:00 from coronavirus
The rapid emergence of viruses with pandemic potential continues to pose a threat to public health worldwide. With the typical drug discovery pipeline taking an average of 5-10 years to reach clinical readiness, there is an urgent need f...

» Inhibition of coronaviral exonuclease activity by TRIM-mediated SUMOylation
05/08/25 20:00 from coronavirus
Members of the TRIM E3 ligase family are effectors of the host innate or intrinsic defense against various viruses; however, how specific TRIM proteins antagonize coronavirus infection is still largely elusive. Through an RNAi screen tar...

» Long-term impact of oral cladribine on humoral immunity in multiple sclerosis
05/08/25 20:00 from coronavirus
CONCLUSION: These long-term data suggest that CLAD treatment does not impact preexisting humoral immunity or antibody production toward novel antigens. Our results support the positive long-term safety profile of the drug.

» Understanding COVID-19 booster information seeking in a collectivist context: the roles of social expectations, trust in experts, and uncertainty
05/08/25 20:00 from coronavirus
CONCLUSION: Findings highlight the need to incorporate social norms, trust relationships, and uncertainty management into public health education campaigns to support vaccine promotion. This study offers empirical evidence for designing ...

» Comparison of Infection-Induced SARS-CoV-2 Seroprevalence Across Large-Scale Residual Samples From Blood Donors, Commercial Laboratories, and Health Checkups in Japan, 2023
05/08/25 20:00 from coronavirus
We compared severe acute respiratory syndrome coronavirus 2 nucleocapsid antibody seroprevalence using 3 types of residual blood samples simultaneously collected in November-December 2023 from blood donors, commercial laboratories, and h...

» Single-Organ Vasculitis Following COVID-19 Infection Resulting in Visceral Arterial Rupture: A Case Report
05/08/25 20:00 from coronavirus
We present the case of a male in his 50s who developed sudden abdominal pain two days after testing positive for coronavirus disease 2019 (COVID-19) and was brought to the emergency department in shock. An emergency laparotomy revealed i...

» Smart working and active mobility for reducing CO2 emissions from the home-to-work commute: the results of the Climactions project
05/08/25 20:00 from coronavirus
CONCLUSIONS: in Italy, road transport accounts for approximately 25% of the total CO2 emissions. The lockdown provided a natural scenario for reducing emissions in urban areas, and the implementation of smart working was associated with ...

» Adenovirus-Based Single-Dose Vaccines for SARS-CoV-2: A Review
05/08/25 20:00 from coronavirus
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak has many unexpected implications, but the scientific community remains optimistic about overcoming these obstacles. Adenoviruses (Ad) are considered the most suita...

» Deployed in Disaster: Perspectives of Personnel Deployed in Ontario Long-Term Care During the Pandemic
05/08/25 20:00 from coronavirus
AIM: The aim of the study is to explore the experience and perspectives of healthcare personnel deployed from the hospitals and military into long-term care (LTC) in Ontario during the pandemic.

» The spatiotemporal dynamics of COVID-19 in Europe: time-series clustering maps 5 distinct trajectories to spatial patterns
05/08/25 20:00 from coronavirus
The COVID-19 pandemic affected Europe unevenly, with surges in infections and deaths fluctuating across different regions and time periods. Hyper-localised hotspots and staggered timelines created intense, asynchronous waves of infection...

» Long-term impact of the SARS-CoV-2 pandemic on respiratory viruses in Germany
05/08/25 20:00 from coronavirus
CONCLUSION: The SARS-CoV-2 pandemic had a considerable impact on the occurrence and seasonality of other respiratory viruses. While nearly all seasonality patterns were initially disrupted due to the heavy non-pharmaceutical intervention...

» Decreases in chimpanzee respiratory disease signs and enteric viral quantity following implementation of anthroponotic disease prevention protocols at a long-term research site
05/08/25 20:00 from Covid-19 origins
Diseases transmitted from humans (i.e., anthroponotic diseases or anthroponoses) are among the leading causes of ill health and mortality for wild chimpanzees (Pan troglodytes). Although various health and hygiene protocols have been pro...

» Coronavirus protein interaction mapping in bat and human cells identifies molecular and genetic switches for immune evasion and replication
05/08/25 20:00 from Covid-19 origins
Coronaviruses, including SARS-CoV-2, can cause severe disease in humans, whereas reservoir hosts like Rhinolophus bats remain asymptomatic. To investigate how host-specific protein-protein interactions (PPIs) influence infection, we gene...

» CRISPR.BOT an autonomous platform for streamlined genetic engineering and molecular biology applications
05/08/25 20:00 from covid-19
In the realm of synthetic biology, the pursuit of streamlined experimental processes has given rise to innovative technologies poised to redefine research paradigms. Traditional workflows, laden with laborious and error-prone stages, inc...

» Using COVID-19 pandemic perturbation to model RSV-hMPV interactions and potential implications under RSV interventions
05/08/25 20:00 from coronavirus
Respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) are closely related pathogens responsible for a significant burden of acute respiratory infections. Interactions between RSV and hMPV have been hypothesized, but the mech...

» Epidemiological Characteristics of MERS-CoV Human Cases, 2012- 2025
05/08/25 20:00 from coronavirus
CONCLUSION: Between 2012 and May 2025, the majority of MERS-CoV infections occurred in the Kingdom of Saudi Arabia and had a high mortality, reaching 40%. Although most cases were reported between 2014 and 2015, new human cases are still...

» CRISPR.BOT an autonomous platform for streamlined genetic engineering and molecular biology applications
05/08/25 20:00 from sars-cov-2
In the realm of synthetic biology, the pursuit of streamlined experimental processes has given rise to innovative technologies poised to redefine research paradigms. Traditional workflows, laden with laborious and error-prone stages, inc...

» Evolving clinical features of Mycoplasma pneumoniae infections following COVID-19 pandemic restrictions: a retrospective, comparative cohort study
05/08/25 20:00 from coronavirus
CONCLUSION: We observed notable changes in the clinical presentation of re-emerging M. pneumoniae infections compared to the pre-COVID-19 pandemic period, particularly an increase in obstructive phenotypes and pleural effusions. However,...

» Incidence and risk factors of new-onset hypertension up to 3 years post SARS-CoV-2 infection
05/08/25 20:00 from coronavirus
COVID-19 can trigger new cardiovascular events, including hypertension, in the acute setting. However, few studies have reported sustained new-onset hypertension post-infection. Moreover, these studies have a small sample size, inadequat...

» A truncated N protein-based ELISA method for the detection of antibodies against porcine deltacoronavirus
05/08/25 20:00 from covid-19 and viral infections in pigs
This study aims to establish an antibody detection method for porcine deltacoronavirus (PDCoV). The recombinant proteins PDCoV-N1 and PDCoV-N2 were expressed via the prokaryotic plasmid pColdII harboring the N gene sequence of the PDCoV ...

» Feasibility of an unsupervised aerobic exercise training program for participants with persistent symptoms after SARS-CoV-2 infection
05/08/25 20:00 from coronavirus
Aim of the randomized controlled pilot study was to investigate general feasibility in terms of adherence to a 12-week unsupervised aerobic exercise training program in participants with persistent symptoms (fatigue, concentration proble...

» Role of rehabilitation in palliative care after the COVID-19 pandemic: a narrative review
05/08/25 20:00 from coronavirus
CONCLUSIONS: The COVID-19 global pandemic highlighted the need for high quality, coordinated palliative care, including rehabilitation services, for patients facing a serious or life-threatening illness. Due to the benefits to a person's...

» Using COVID-19 pandemic perturbation to model RSV-hMPV interactions and potential implications under RSV interventions
05/08/25 20:00 from sars-cov-2
Respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) are closely related pathogens responsible for a significant burden of acute respiratory infections. Interactions between RSV and hMPV have been hypothesized, but the mech...

» Research progress in active substances and their mechanisms of action against porcine epidemic diarrhea virus
05/08/25 20:00 from covid-19 and viral infections in pigs
Porcine epidemic diarrhea virus (PEDV) is an intestinal coronavirus that can cause porcine epidemic diarrhea, leading to diarrhea, vomiting, weight loss, and even death in piglets. Due to the diversity of PEDV strains, traditional vaccin...

» Genome-wide CRISPR screen reveals key role of sialic acids in PEDV and porcine coronavirus infections
05/08/25 20:00 from covid-19 and viral infections in pigs
Porcine epidemic diarrhea virus (PEDV) is a globally distributed alphacoronavirus with economic importance that can cause severe watery diarrhea and even death in piglets. To identify host factors essential for PEDV infection, we perform...

» A truncated N protein-based ELISA method for the detection of antibodies against porcine deltacoronavirus
05/08/25 20:00 from Coronavirus and African Swine Fever Virus
This study aims to establish an antibody detection method for porcine deltacoronavirus (PDCoV). The recombinant proteins PDCoV-N1 and PDCoV-N2 were expressed via the prokaryotic plasmid pColdII harboring the N gene sequence of the PDCoV ...

» From Inflammation to Flooding: COVID-19, Asthma, and Pulmonary Edema
05/08/25 20:00 from coronavirus
The respiratory system, like many other body systems, undergoes significant changes during pregnancy to support the needs of the growing fetus. This article begins by providing a detailed overview of these normal physiologic changes, hig...

» Intranasal measles virus- and mumps virus-based SARS-CoV-2 vaccine candidates prevent SARS-CoV-2 infection and transmission
05/08/25 20:00 from sars-cov-2 spike protein
The emergence of immune-evasive SARS-CoV-2 Omicron subvariants highlights the need to develop a mucosal SARS-CoV-2 vaccine that can provide broad protection against virus infection and transmission. Here, we developed an intranasal monov...

» Evolving clinical features of Mycoplasma pneumoniae infections following COVID-19 pandemic restrictions: a retrospective, comparative cohort study
05/08/25 20:00 from sars-cov-2
CONCLUSION: We observed notable changes in the clinical presentation of re-emerging M. pneumoniae infections compared to the pre-COVID-19 pandemic period, particularly an increase in obstructive phenotypes and pleural effusions. However,...

» Relationship between COVID-19 stigma and anxiety symptoms in university students during the COVID-19 pandemic
05/08/25 20:00 from sars-cov-2
CONCLUSION: We recommend developing appropriate strategies for safeguards, such as the dissemination of relevant knowledge to at-risk populations, to cope with stigmatizing attitudes and anxiety symptoms among university students.

» Association between encephalopathy and clinical outcomes of COVID-19: Findings from the Philippine CORONA Study
05/08/25 20:00 from coronavirus
CONCLUSIONS: Encephalopathy was associated with COVID-19 severity, mortality, respiratory failure, ICU admission, and longer hospital stays.

» Corona VRus Coaster: the virtual reality roller coaster of the proteins of SARS-CoV-2
05/08/25 20:00 from sars-cov-2 spike protein
CONTEXT: The COVID-19 pandemic, caused by SARS-CoV-2, has driven significant research into the virus' structural components to elucidate its infection mechanisms and advance therapeutic strategies. However, the intricate architecture of ...

» Using COVID-19 pandemic perturbation to model RSV-hMPV interactions and potential implications under RSV interventions
05/08/25 20:00 from covid-19
Respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) are closely related pathogens responsible for a significant burden of acute respiratory infections. Interactions between RSV and hMPV have been hypothesized, but the mech...

» Incidence and risk factors of new-onset hypertension up to 3 years post SARS-CoV-2 infection
05/08/25 20:00 from sars-cov-2
COVID-19 can trigger new cardiovascular events, including hypertension, in the acute setting. However, few studies have reported sustained new-onset hypertension post-infection. Moreover, these studies have a small sample size, inadequat...

» A truncated N protein-based ELISA method for the detection of antibodies against porcine deltacoronavirus
05/08/25 20:00 from coronavirus
This study aims to establish an antibody detection method for porcine deltacoronavirus (PDCoV). The recombinant proteins PDCoV-N1 and PDCoV-N2 were expressed via the prokaryotic plasmid pColdII harboring the N gene sequence of the PDCoV ...

» Epidemiological Characteristics of MERS-CoV Human Cases, 2012- 2025
05/08/25 20:00 from covid-19
CONCLUSION: Between 2012 and May 2025, the majority of MERS-CoV infections occurred in the Kingdom of Saudi Arabia and had a high mortality, reaching 40%. Although most cases were reported between 2014 and 2015, new human cases are still...

» Modeling Antibody Kinetics Post-mRNA Booster Vaccination and Protection Durations Against SARS-CoV-2 Infection
05/08/25 20:00 from sars-cov-2 spike protein
Understanding the dynamics of SARS-CoV-2 antibody levels post-booster vaccination is important to inform their durations of protection. Longitudinal antibody data was collected on the day of booster vaccination, as well as 28, 180, and 3...

» Feasibility of an unsupervised aerobic exercise training program for participants with persistent symptoms after SARS-CoV-2 infection
05/08/25 20:00 from sars-cov-2
Aim of the randomized controlled pilot study was to investigate general feasibility in terms of adherence to a 12-week unsupervised aerobic exercise training program in participants with persistent symptoms (fatigue, concentration proble...

» Evolving clinical features of Mycoplasma pneumoniae infections following COVID-19 pandemic restrictions: a retrospective, comparative cohort study
05/08/25 20:00 from covid-19
CONCLUSION: We observed notable changes in the clinical presentation of re-emerging M. pneumoniae infections compared to the pre-COVID-19 pandemic period, particularly an increase in obstructive phenotypes and pleural effusions. However,...

» Research progress in active substances and their mechanisms of action against porcine epidemic diarrhea virus
05/08/25 20:00 from coronavirus
Porcine epidemic diarrhea virus (PEDV) is an intestinal coronavirus that can cause porcine epidemic diarrhea, leading to diarrhea, vomiting, weight loss, and even death in piglets. Due to the diversity of PEDV strains, traditional vaccin...

» Role of rehabilitation in palliative care after the COVID-19 pandemic: a narrative review
05/08/25 20:00 from sars-cov-2
CONCLUSIONS: The COVID-19 global pandemic highlighted the need for high quality, coordinated palliative care, including rehabilitation services, for patients facing a serious or life-threatening illness. Due to the benefits to a person's...

» Exploring the COVID-19 pandemic's impact on mood, anxiety, and neurocognitive disorders in older adults: sex, geographic context, and healthcare setting considerations
05/08/25 20:00 from covid-19
CONCLUSION: Psychiatric presentations varied by disorder, influenced by demographic and contextual factors. Healthcare setting was a significant predictor across all disorders. The lack of pandemic-related effects suggests a consistent i...

» ECMO Timing and Intracranial Hemorrhage in Coronavirus Patients: Insights for Future Epidemics
05/08/25 20:00 from coronavirus
CONCLUSIONS: Later ECMO initiation, when combined with signs of respiratory and metabolic decompensation, was was associated with a higher risk of ICH in coronavirus patients. These findings emphasize the importance of timely ECMO interv...

» Amyloidogenic SARS-CoV-2 Spike Protein-Derived Peptides Form Oligomers and Selectively Damage Lipid Membranes
05/08/25 20:00 from sars-cov-2 spike protein
Several peptides derived from the SARS-CoV-2 spike protein (S-protein) are amyloidogenic, suggesting a potential role in COVID-19 disease-associated pathogenesis. Many disease-related amyloids form a variety of intermediate oligomeric ag...

» Carfilzomib-lenalidomide-dexamethasone versus lenalidomide-dexamethasone in patients with newly diagnosed myeloma ineligible for autologous stem-cell transplantation (EMN20): a randomised, open-label, multicentre, phase 3 trial
05/08/25 20:00 from sars-cov-2
BACKGROUND: Before the introduction of daratumumab-lenalidomide-dexamethasone as a first-line treatment for patients with newly diagnosed transplant-ineligible multiple myeloma, lenalidomide-dexamethasone was a standard of care. We aimed...

» Relationship between COVID-19 stigma and anxiety symptoms in university students during the COVID-19 pandemic
05/08/25 20:00 from covid-19
CONCLUSION: We recommend developing appropriate strategies for safeguards, such as the dissemination of relevant knowledge to at-risk populations, to cope with stigmatizing attitudes and anxiety symptoms among university students.

» Unlocking Nature's Hidden Treasures: Actinomycetota's Arsenal of Potent Antiviral Compounds Against Human Viral Infections
05/08/25 20:00 from coronavirus
The global emergence of infectious diseases, including COVID-19, Mpox, MERS, Ebola, dengue, Zika, and avian influenza, alongside the escalation of antimicrobial resistance, has made the discovery of novel antiviral agents an urgent prior...

» From Inflammation to Flooding: COVID-19, Asthma, and Pulmonary Edema
05/08/25 20:00 from sars-cov-2
The respiratory system, like many other body systems, undergoes significant changes during pregnancy to support the needs of the growing fetus. This article begins by providing a detailed overview of these normal physiologic changes, hig...

» Coronavirus protein interaction mapping in bat and human cells identifies molecular and genetic switches for immune evasion and replication
05/08/25 20:00 from Coronavirus origins
Coronaviruses, including SARS-CoV-2, can cause severe disease in humans, whereas reservoir hosts like Rhinolophus bats remain asymptomatic. To investigate how host-specific protein-protein interactions (PPIs) influence infection, we gene...

» Incidence and risk factors of new-onset hypertension up to 3 years post SARS-CoV-2 infection
05/08/25 20:00 from covid-19
COVID-19 can trigger new cardiovascular events, including hypertension, in the acute setting. However, few studies have reported sustained new-onset hypertension post-infection. Moreover, these studies have a small sample size, inadequat...

» Point-of-need one-pot multiplexed RT-LAMP test for detecting three common respiratory viruses in saliva
05/08/25 20:00 from coronavirus
Respiratory viral infections pose a significant global public health challenge, partly due to the difficulty in rapidly and accurately distinguishing between viruses with similar symptoms at the point of care, hindering timely and approp...

» Association between encephalopathy and clinical outcomes of COVID-19: Findings from the Philippine CORONA Study
05/08/25 20:00 from sars-cov-2
CONCLUSIONS: Encephalopathy was associated with COVID-19 severity, mortality, respiratory failure, ICU admission, and longer hospital stays.

» Enhancing image retrieval through optimal barcode representation
05/08/25 20:00 from covid-19
Data binary encoding has proven to be a versatile tool for optimizing data processing and memory efficiency in various machine learning applications. This includes deep barcoding, generating barcodes from deep learning feature extraction...

» Excess Mortality and Containment Performance During the COVID-19 Pandemic: Evidence From 34 Countries
05/08/25 20:00 from coronavirus
Objectives. To expand COVID-19 containment indicators to evaluate the relationship between excess mortality and government response. Methods. We developed a longitudinal study analyzing excess mortality, COVID-19 containment, and structu...

» SARS-CoV-2, influenza, HRSV and other respiratory pathogens during the post-COVID-19 era: Epidemic circulation in Italy in the 2023/2024 season
05/08/25 20:00 from sars-cov-2
CONCLUSIONS: This study contributes to the understanding of the spread of respiratory viruses and the genetic characteristics of SARS-CoV-2 and influenza in patients with SARI, underlining the importance of continuous surveillance.

» Feasibility of an unsupervised aerobic exercise training program for participants with persistent symptoms after SARS-CoV-2 infection
05/08/25 20:00 from covid-19
Aim of the randomized controlled pilot study was to investigate general feasibility in terms of adherence to a 12-week unsupervised aerobic exercise training program in participants with persistent symptoms (fatigue, concentration proble...

» Integrated horizontal convective PCR system for clinical diagnostics
05/08/25 20:00 from coronavirus
Rapid and accurate disease diagnosis in resource-limited settings is critical for optimizing medical resources and controlling epidemic outbreaks. However, developing a point-of-care detection system that is user-friendly, cost-effective...

» Coronavirus protein interaction mapping in bat and human cells identifies molecular and genetic switches for immune evasion and replication
05/08/25 20:00 from Sars-Cov-2 origins
Coronaviruses, including SARS-CoV-2, can cause severe disease in humans, whereas reservoir hosts like Rhinolophus bats remain asymptomatic. To investigate how host-specific protein-protein interactions (PPIs) influence infection, we gene...

» Point-of-need one-pot multiplexed RT-LAMP test for detecting three common respiratory viruses in saliva
05/08/25 20:00 from sars-cov-2
Respiratory viral infections pose a significant global public health challenge, partly due to the difficulty in rapidly and accurately distinguishing between viruses with similar symptoms at the point of care, hindering timely and approp...

» Top 10 drugs most frequently associated with adverse events of myocarditis and pericarditis
05/08/25 20:00 from covid-19
Myocarditis and pericarditis are managed with various treatments, yet prior studies and case reports indicate that certain drug classes may elevate the risk for these inflammatory cardiac conditions. This research aimed to systematically...

» Modelling the dynamics of SARS-CoV-2 during the first 14 days of infection
05/08/25 20:00 from sars-cov-2
Interpreting the viral mechanism of SARS-CoV-2 based on the human body level is critical for developing more efficient interventions. Due to the limitation of data, limited models consider the viral dynamics of the early phase of infecti...

» Role of rehabilitation in palliative care after the COVID-19 pandemic: a narrative review
05/08/25 20:00 from covid-19
CONCLUSIONS: The COVID-19 global pandemic highlighted the need for high quality, coordinated palliative care, including rehabilitation services, for patients facing a serious or life-threatening illness. Due to the benefits to a person's...

» Comparison of Infection-Induced SARS-CoV-2 Seroprevalence Across Large-Scale Residual Samples From Blood Donors, Commercial Laboratories, and Health Checkups in Japan, 2023
05/08/25 20:00 from SARS-CoV-2 and Sars-Cov comparisons
We compared severe acute respiratory syndrome coronavirus 2 nucleocapsid antibody seroprevalence using 3 types of residual blood samples simultaneously collected in November-December 2023 from blood donors, commercial laboratories, and h...

» Memory T cell reactivity to a broad range of conserved SARS-CoV-2-derived ORF1ab epitopes in first wave COVID-19 convalescents
05/08/25 20:00 from sars-cov-2
CONCLUSION: SARS-CoV-2 ORF1ab-derived HLA class 1 peptides, particularly WSMATYYLF, YVFCTVNAL, and LMIERFVSL, induce durable memory CD8^(+) T cell responses in COVID-19 convalescents. The correlation between T cell responses and the time...

» Carfilzomib-lenalidomide-dexamethasone versus lenalidomide-dexamethasone in patients with newly diagnosed myeloma ineligible for autologous stem-cell transplantation (EMN20): a randomised, open-label, multicentre, phase 3 trial
05/08/25 20:00 from covid-19
BACKGROUND: Before the introduction of daratumumab-lenalidomide-dexamethasone as a first-line treatment for patients with newly diagnosed transplant-ineligible multiple myeloma, lenalidomide-dexamethasone was a standard of care. We aimed...

» Early T cell responses correlate with SARS-CoV-2 viral clearance
05/08/25 20:00 from sars-cov-2
No abstract

» From Inflammation to Flooding: COVID-19, Asthma, and Pulmonary Edema
05/08/25 20:00 from covid-19
The respiratory system, like many other body systems, undergoes significant changes during pregnancy to support the needs of the growing fetus. This article begins by providing a detailed overview of these normal physiologic changes, hig...

» Association between encephalopathy and clinical outcomes of COVID-19: Findings from the Philippine CORONA Study
05/08/25 20:00 from covid-19
CONCLUSIONS: Encephalopathy was associated with COVID-19 severity, mortality, respiratory failure, ICU admission, and longer hospital stays.

» A truncated N protein-based ELISA method for the detection of antibodies against porcine deltacoronavirus
05/08/25 20:00 from covid-19
This study aims to establish an antibody detection method for porcine deltacoronavirus (PDCoV). The recombinant proteins PDCoV-N1 and PDCoV-N2 were expressed via the prokaryotic plasmid pColdII harboring the N gene sequence of the PDCoV ...

» Decreases in chimpanzee respiratory disease signs and enteric viral quantity following implementation of anthroponotic disease prevention protocols at a long-term research site
05/08/25 20:00 from Covid-19 origins
Diseases transmitted from humans (i.e., anthroponotic diseases or anthroponoses) are among the leading causes of ill health and mortality for wild chimpanzees (Pan troglodytes). Although various health and hygiene protocols have been pro...

» Coronavirus protein interaction mapping in bat and human cells identifies molecular and genetic switches for immune evasion and replication
05/08/25 20:00 from Sars-Cov-2 origins
Coronaviruses, including SARS-CoV-2, can cause severe disease in humans, whereas reservoir hosts like Rhinolophus bats remain asymptomatic. To investigate how host-specific protein-protein interactions (PPIs) influence infection, we gene...

» Coronavirus protein interaction mapping in bat and human cells identifies molecular and genetic switches for immune evasion and replication
05/08/25 20:00 from Covid-19 origins
Coronaviruses, including SARS-CoV-2, can cause severe disease in humans, whereas reservoir hosts like Rhinolophus bats remain asymptomatic. To investigate how host-specific protein-protein interactions (PPIs) influence infection, we gene...

» A truncated N protein-based ELISA method for the detection of antibodies against porcine deltacoronavirus
05/08/25 20:00 from Coronavirus and African Swine Fever Virus
This study aims to establish an antibody detection method for porcine deltacoronavirus (PDCoV). The recombinant proteins PDCoV-N1 and PDCoV-N2 were expressed via the prokaryotic plasmid pColdII harboring the N gene sequence of the PDCoV ...

» A truncated N protein-based ELISA method for the detection of antibodies against porcine deltacoronavirus
05/08/25 20:00 from covid-19 and viral infections in pigs
This study aims to establish an antibody detection method for porcine deltacoronavirus (PDCoV). The recombinant proteins PDCoV-N1 and PDCoV-N2 were expressed via the prokaryotic plasmid pColdII harboring the N gene sequence of the PDCoV ...

» Research progress in active substances and their mechanisms of action against porcine epidemic diarrhea virus
05/08/25 20:00 from covid-19 and viral infections in pigs
Porcine epidemic diarrhea virus (PEDV) is an intestinal coronavirus that can cause porcine epidemic diarrhea, leading to diarrhea, vomiting, weight loss, and even death in piglets. Due to the diversity of PEDV strains, traditional vaccin...

» Genome-wide CRISPR screen reveals key role of sialic acids in PEDV and porcine coronavirus infections
05/08/25 20:00 from covid-19 and viral infections in pigs
Porcine epidemic diarrhea virus (PEDV) is a globally distributed alphacoronavirus with economic importance that can cause severe watery diarrhea and even death in piglets. To identify host factors essential for PEDV infection, we perform...

» Coronavirus protein interaction mapping in bat and human cells identifies molecular and genetic switches for immune evasion and replication
05/08/25 20:00 from Coronavirus origins
Coronaviruses, including SARS-CoV-2, can cause severe disease in humans, whereas reservoir hosts like Rhinolophus bats remain asymptomatic. To investigate how host-specific protein-protein interactions (PPIs) influence infection, we gene...

» Intranasal measles virus- and mumps virus-based SARS-CoV-2 vaccine candidates prevent SARS-CoV-2 infection and transmission
05/08/25 20:00 from sars-cov-2 spike protein
The emergence of immune-evasive SARS-CoV-2 Omicron subvariants highlights the need to develop a mucosal SARS-CoV-2 vaccine that can provide broad protection against virus infection and transmission. Here, we developed an intranasal monov...

» Corona VRus Coaster: the virtual reality roller coaster of the proteins of SARS-CoV-2
05/08/25 20:00 from sars-cov-2 spike protein
CONTEXT: The COVID-19 pandemic, caused by SARS-CoV-2, has driven significant research into the virus' structural components to elucidate its infection mechanisms and advance therapeutic strategies. However, the intricate architecture of ...

» Modeling Antibody Kinetics Post-mRNA Booster Vaccination and Protection Durations Against SARS-CoV-2 Infection
05/08/25 20:00 from sars-cov-2 spike protein
Understanding the dynamics of SARS-CoV-2 antibody levels post-booster vaccination is important to inform their durations of protection. Longitudinal antibody data was collected on the day of booster vaccination, as well as 28, 180, and 3...

» Amyloidogenic SARS-CoV-2 Spike Protein-Derived Peptides Form Oligomers and Selectively Damage Lipid Membranes
05/08/25 20:00 from sars-cov-2 spike protein
Several peptides derived from the SARS-CoV-2 spike protein (S-protein) are amyloidogenic, suggesting a potential role in COVID-19 disease-associated pathogenesis. Many disease-related amyloids form a variety of intermediate oligomeric ag...

» Comparison of Infection-Induced SARS-CoV-2 Seroprevalence Across Large-Scale Residual Samples From Blood Donors, Commercial Laboratories, and Health Checkups in Japan, 2023
05/08/25 20:00 from SARS-CoV-2 and Sars-Cov comparisons
We compared severe acute respiratory syndrome coronavirus 2 nucleocapsid antibody seroprevalence using 3 types of residual blood samples simultaneously collected in November-December 2023 from blood donors, commercial laboratories, and h...

» A truncated N protein-based ELISA method for the detection of antibodies against porcine deltacoronavirus
05/08/25 20:00 from Coronavirus and African Swine Fever Virus
This study aims to establish an antibody detection method for porcine deltacoronavirus (PDCoV). The recombinant proteins PDCoV-N1 and PDCoV-N2 were expressed via the prokaryotic plasmid pColdII harboring the N gene sequence of the PDCoV ...

» Coronavirus protein interaction mapping in bat and human cells identifies molecular and genetic switches for immune evasion and replication
05/08/25 20:00 from Sars-Cov-2 origins
Coronaviruses, including SARS-CoV-2, can cause severe disease in humans, whereas reservoir hosts like Rhinolophus bats remain asymptomatic. To investigate how host-specific protein-protein interactions (PPIs) influence infection, we gene...

» Intranasal measles virus- and mumps virus-based SARS-CoV-2 vaccine candidates prevent SARS-CoV-2 infection and transmission
05/08/25 20:00 from sars-cov-2 spike protein
The emergence of immune-evasive SARS-CoV-2 Omicron subvariants highlights the need to develop a mucosal SARS-CoV-2 vaccine that can provide broad protection against virus infection and transmission. Here, we developed an intranasal monov...

» Coronavirus protein interaction mapping in bat and human cells identifies molecular and genetic switches for immune evasion and replication
05/08/25 20:00 from Coronavirus origins
Coronaviruses, including SARS-CoV-2, can cause severe disease in humans, whereas reservoir hosts like Rhinolophus bats remain asymptomatic. To investigate how host-specific protein-protein interactions (PPIs) influence infection, we gene...

» Corona VRus Coaster: the virtual reality roller coaster of the proteins of SARS-CoV-2
05/08/25 20:00 from sars-cov-2 spike protein
CONTEXT: The COVID-19 pandemic, caused by SARS-CoV-2, has driven significant research into the virus' structural components to elucidate its infection mechanisms and advance therapeutic strategies. However, the intricate architecture of ...

» Modeling Antibody Kinetics Post-mRNA Booster Vaccination and Protection Durations Against SARS-CoV-2 Infection
05/08/25 20:00 from sars-cov-2 spike protein
Understanding the dynamics of SARS-CoV-2 antibody levels post-booster vaccination is important to inform their durations of protection. Longitudinal antibody data was collected on the day of booster vaccination, as well as 28, 180, and 3...

» Amyloidogenic SARS-CoV-2 Spike Protein-Derived Peptides Form Oligomers and Selectively Damage Lipid Membranes
05/08/25 20:00 from sars-cov-2 spike protein
Several peptides derived from the SARS-CoV-2 spike protein (S-protein) are amyloidogenic, suggesting a potential role in COVID-19 disease-associated pathogenesis. Many disease-related amyloids form a variety of intermediate oligomeric ag...

» Decreases in chimpanzee respiratory disease signs and enteric viral quantity following implementation of anthroponotic disease prevention protocols at a long-term research site
05/08/25 20:00 from Covid-19 origins
Diseases transmitted from humans (i.e., anthroponotic diseases or anthroponoses) are among the leading causes of ill health and mortality for wild chimpanzees (Pan troglodytes). Although various health and hygiene protocols have been pro...

» Coronavirus protein interaction mapping in bat and human cells identifies molecular and genetic switches for immune evasion and replication
05/08/25 20:00 from Covid-19 origins
Coronaviruses, including SARS-CoV-2, can cause severe disease in humans, whereas reservoir hosts like Rhinolophus bats remain asymptomatic. To investigate how host-specific protein-protein interactions (PPIs) influence infection, we gene...

» A truncated N protein-based ELISA method for the detection of antibodies against porcine deltacoronavirus
05/08/25 20:00 from covid-19 and viral infections in pigs
This study aims to establish an antibody detection method for porcine deltacoronavirus (PDCoV). The recombinant proteins PDCoV-N1 and PDCoV-N2 were expressed via the prokaryotic plasmid pColdII harboring the N gene sequence of the PDCoV ...

» Comparison of Infection-Induced SARS-CoV-2 Seroprevalence Across Large-Scale Residual Samples From Blood Donors, Commercial Laboratories, and Health Checkups in Japan, 2023
05/08/25 20:00 from SARS-CoV-2 and Sars-Cov comparisons
We compared severe acute respiratory syndrome coronavirus 2 nucleocapsid antibody seroprevalence using 3 types of residual blood samples simultaneously collected in November-December 2023 from blood donors, commercial laboratories, and h...

» Research progress in active substances and their mechanisms of action against porcine epidemic diarrhea virus
05/08/25 20:00 from covid-19 and viral infections in pigs
Porcine epidemic diarrhea virus (PEDV) is an intestinal coronavirus that can cause porcine epidemic diarrhea, leading to diarrhea, vomiting, weight loss, and even death in piglets. Due to the diversity of PEDV strains, traditional vaccin...

» Genome-wide CRISPR screen reveals key role of sialic acids in PEDV and porcine coronavirus infections
05/08/25 20:00 from covid-19 and viral infections in pigs
Porcine epidemic diarrhea virus (PEDV) is a globally distributed alphacoronavirus with economic importance that can cause severe watery diarrhea and even death in piglets. To identify host factors essential for PEDV infection, we perform...

» Functional antibody responses to SARS-CoV-2 variants before and after booster vaccination among adults in Ghana
04/08/25 20:00 from coronavirus
COVID-19 booster vaccinations are needed to enhance waning immunity and the emergence of new variants. In Africa, where COVID-19 vaccine coverage is low, there is a paucity of data on COVID-19 vaccine-induced immunity, particularly in th...

» Functional antibody responses to SARS-CoV-2 variants before and after booster vaccination among adults in Ghana
04/08/25 20:00 from sars-cov-2 spike protein
COVID-19 booster vaccinations are needed to enhance waning immunity and the emergence of new variants. In Africa, where COVID-19 vaccine coverage is low, there is a paucity of data on COVID-19 vaccine-induced immunity, particularly in th...

» SARS-CoV-2 spike treatment and transfection impairs airway epithelial repair
04/08/25 20:00 from coronavirus
CONCLUSIONS: SARS-CoV-2 spike S1 treatment and transfection can alter measures of proliferation and inflammation as well as impair wound closure of 16HBE14o- airway epithelial cells. These results highlight how components of SARS-CoV-2 c...

» ARDS severity in COVID-19: a case-control study of laboratory biomarkers and IL-10 SNP analysis
04/08/25 20:00 from coronavirus
CONCLUSION: Hematological indices (neutrophil count and NLR), CRP, and serum IL-10 hold promise in monitoring ARDS severity in COVID-19 patients. In addition, COVID-19 patients with GG and AG genotypes and the G allele of the IL-10 gene'...

» Prognostic Value of Peripheral Blood nCD64 Index, mHLA-DR, and CD14⁺monocyte Percentage in Different Infection Status in COVID-19 Patients
04/08/25 20:00 from coronavirus
CONCLUSION: The nCD64 index, mHLA-DR level, and percentage of CD14^(+) monocytes may serve as biomarkers for predicting clinical outcomes in COVID-19 patients.

» Triterpene saponins from the halophyte Anabasis setifera exhibit anti-SARS-CoV-2 properties
04/08/25 20:00 from sars-cov-2
Halophytes are well-known as a rich source of health-promoting phytochemicals. This study aimed to elucidate the chemical constituents and antiviral potential of the halophyte Anabasis setifera Moq., growing in the desert areas of Egypt....

» Abnormal uterine bleeding and fertility challenges secondary to long COVID: A case report
04/08/25 20:00 from coronavirus
Menstrual irregularities and abnormal uterine bleeding have been increasingly reported following severe acute respiratory syndrome coronavirus 2 infection, likely due to viral-induced endocrine disruption and immune dysregulation. A woma...

» Pauci-immune glomerulonephritis: Post-COVID kidney disease continues to reappear, a case report
04/08/25 20:00 from coronavirus
We present a female in her mid-70s with COVID-19 infection who developed worsening renal function along with systemic symptoms over months. The patient was initially monitored for long COVID and was referred to the nephrologist after she...

» Neurologic symptoms following COVID-19 in Lima, Peru: a prospective longitudinal observational study
04/08/25 20:00 from SARS-CoV-2 and Sars-Cov comparisons
INTRODUCTION: There is limited research on long-term neurologic symptoms following SARS-CoV-2 infection in Peru. This study aimed to describe the longitudinal experience of survivors of mild to moderate COVID-19 in Lima, Peru.

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