Covid-19 Pubmed Articles

Covid-19 Pubmed Articles
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» Incidence and characteristics of Guillain-Barré syndrome in Taiwan before and during the COVID-19 pandemic: A 12-year single-center experience
29/05/25 20:00 from coronavirus
CONCLUSION: This single-center study found no increase in GBS occurrence during the COVID-19 pandemic. In Taiwan, GBS is characterized by a higher occurrence of MFS and GBS/MFS overlap and more frequent axonal GBS, highlighting geographi...

» Incidence and characteristics of Guillain-Barre syndrome in Taiwan before and during the COVID-19 pandemic: A 12-year single-center experience
29/05/25 20:00 from covid-19
CONCLUSION: This single-center study found no increase in GBS occurrence during the COVID-19 pandemic. In Taiwan, GBS is characterized by a higher occurrence of MFS and GBS/MFS overlap and more frequent axonal GBS, highlighting geographi...

» The Indirect Impact of COVID-19 Pandemic on Mortality, Complications, and Healthcare Utilization Among Patients With Chronic Respiratory Diseases in Hong Kong: An Interrupted Time Series Analysis
29/05/25 20:00 from coronavirus
CONCLUSION: The disruption of usual healthcare impacts mortality rates among patients with CRD without COVID-19, particularly nonrespiratory mortality. Contingency plans on continuing follow-up and monitoring of CRD patients are needed, ...

» The Indirect Impact of COVID-19 Pandemic on Mortality, Complications, and Healthcare Utilization Among Patients With Chronic Respiratory Diseases in Hong Kong: An Interrupted Time Series Analysis
29/05/25 20:00 from covid-19
CONCLUSION: The disruption of usual healthcare impacts mortality rates among patients with CRD without COVID-19, particularly nonrespiratory mortality. Contingency plans on continuing follow-up and monitoring of CRD patients are needed, ...

» Incidence and characteristics of Guillain-Barre syndrome in Taiwan before and during the COVID-19 pandemic: A 12-year single-center experience
29/05/25 20:00 from covid-19
CONCLUSION: This single-center study found no increase in GBS occurrence during the COVID-19 pandemic. In Taiwan, GBS is characterized by a higher occurrence of MFS and GBS/MFS overlap and more frequent axonal GBS, highlighting geographi...

» The Indirect Impact of COVID-19 Pandemic on Mortality, Complications, and Healthcare Utilization Among Patients With Chronic Respiratory Diseases in Hong Kong: An Interrupted Time Series Analysis
29/05/25 20:00 from covid-19
CONCLUSION: The disruption of usual healthcare impacts mortality rates among patients with CRD without COVID-19, particularly nonrespiratory mortality. Contingency plans on continuing follow-up and monitoring of CRD patients are needed, ...

» Incidence and characteristics of Guillain-Barré syndrome in Taiwan before and during the COVID-19 pandemic: A 12-year single-center experience
29/05/25 20:00 from coronavirus
CONCLUSION: This single-center study found no increase in GBS occurrence during the COVID-19 pandemic. In Taiwan, GBS is characterized by a higher occurrence of MFS and GBS/MFS overlap and more frequent axonal GBS, highlighting geographi...

» The Indirect Impact of COVID-19 Pandemic on Mortality, Complications, and Healthcare Utilization Among Patients With Chronic Respiratory Diseases in Hong Kong: An Interrupted Time Series Analysis
29/05/25 20:00 from coronavirus
CONCLUSION: The disruption of usual healthcare impacts mortality rates among patients with CRD without COVID-19, particularly nonrespiratory mortality. Contingency plans on continuing follow-up and monitoring of CRD patients are needed, ...

» Factors Associated With Depression and Anxiety in People With Rare Diseases During COVID-19: A Cross-Sectional Study
29/05/25 20:00 from coronavirus
Background: People living with a rare disease are a vulnerable patient group and experience challenges in participation and healthcare. Due to changes in healthcare and threat of the infection during coronavirus disease 2019 (COVID-19) p...

» Evidence of SARS-CoV-2 bacteriophage potential in human gut microbiota
29/05/25 20:00 from coronavirus
CONCLUSIONS: Based on these results we conclude that, in addition to its well-documented interactions with eukaryotic cells, SARS-CoV-2 may act as a bacteriophage when interacting with at least two bacterial species known to be present i...

» Scaling up of electronic case-based disease surveillance reporting for COVID-19 and other notifiable diseases through capacity building and antigen RDT provision: a case study of Sierra Leone
29/05/25 20:00 from coronavirus
CONCLUSION: The COVID-19 pandemic provided a unique opportunity for the country to scale up eCBDS in more health facilities, and this improved notification and investigation timelines. However, more still needs to be done to ensure count...

» Platypnea-Orthodeoxia and Patent Foramen Ovale in a Patient in the Setting of COVID-19
29/05/25 20:00 from coronavirus
Platypnea-orthodeoxia syndrome is a rare condition characterized by positional dyspnea and hypoxemia, with symptoms presenting in the upright position and improving when recumbent. Hypoxemia in platypnea-orthodeoxia syndrome is defined a...

» The influence of the fourth industrial revolution in teaching and learning: the COVID-19 context
29/05/25 20:00 from coronavirus
CONCLUSIONS: Therefore, we recommended that the government and stakeholders within the education sector provide resources such as smart-boards, computers, and network access in schools lacking such facilities, as well as providing profes...

» Broad-spectrum coronavirus inhibitors discovered by modeling viral fusion dynamics
29/05/25 20:00 from coronavirus
Development of oral, broad-spectrum therapeutics targeting SARS-CoV-2, its variants, and related coronaviruses could curb the spread of COVID-19 and avert future pandemics. We created a novel computational discovery pipeline that employe...

» Waning immunity drives respiratory virus evolution and reinfection
29/05/25 20:00 from coronavirus
Viruses differ in the number and types of host tissues in which they replicate. For example, systemically replicating viruses such as measles infect cells and tissues throughout the body, whereas respiratory viruses such as influenza vir...

» Using Machine Learning to Identify Predictors of Maternal and Infant Hair Cortisol Concentration Before and During the COVID-19 Pandemic
29/05/25 20:00 from covid-19
Hair cortisol concentration (HCC) has been theorized to reflect chronic stress, and maternal and infant HCC may be correlated due to shared genetic, physiological, behavioural, and environmental factors, such as stressful life circumstan...

» Unraveling the Amplification-Free Quantitative Detection of Viral RNA in Nasopharyngeal Swab Samples Using a Compact Electrochemical Rapid Test Device
29/05/25 20:00 from coronavirus
Providing viral load numbers of infection events aids in the identification of disease severity and in the effective overall patient management. Gold-standard polymerase chain reaction (PCR) techniques make this possible but cannot be ap...

» Pathological Glucose Levels Enhance Entry Factor Expression and Hepatic SARS-CoV-2 Infection
29/05/25 20:00 from coronavirus
Accumulating clinical evidence suggests an intricate relationship between severe COVID-19 and preexisting metabolic complications, which share some metabolic dysregulations, including hyperglycaemia, hyperinsulinaemia and hyperlipidaemia...

» Evidence of SARS-CoV-2 bacteriophage potential in human gut microbiota
29/05/25 20:00 from sars-cov-2 spike protein
CONCLUSIONS: Based on these results we conclude that, in addition to its well-documented interactions with eukaryotic cells, SARS-CoV-2 may act as a bacteriophage when interacting with at least two bacterial species known to be present i...

» Suppression of Monkeypox Virus by Downregulation of Fatty Acid Synthase and Upregulation of Cholesterol-25 Hydroxylase
29/05/25 20:00 from covid-19
The World Health Organization declared the spread of monkeypox virus (MPXV) across multiple African countries a public health emergency of international concern in August 2024. This marks the second such declaration in the past 2 years i...

» Incidence and characteristics of Guillain-Barré syndrome in Taiwan before and during the COVID-19 pandemic: A 12-year single-center experience
29/05/25 20:00 from coronavirus
CONCLUSION: This single-center study found no increase in GBS occurrence during the COVID-19 pandemic. In Taiwan, GBS is characterized by a higher occurrence of MFS and GBS/MFS overlap and more frequent axonal GBS, highlighting geographi...

» Paxlovid Is Associated With Lower Rates of Long COVID-19 Smell and Taste Disorders
29/05/25 20:00 from covid-19
CONCLUSIONS: Early intervention with Paxlovid may decrease the risk of long COVID-19 smell/taste changes. Further study with a randomized controlled trial would help providers know more definitively if they should consider this utility i...

» The Indirect Impact of COVID-19 Pandemic on Mortality, Complications, and Healthcare Utilization Among Patients With Chronic Respiratory Diseases in Hong Kong: An Interrupted Time Series Analysis
29/05/25 20:00 from coronavirus
CONCLUSION: The disruption of usual healthcare impacts mortality rates among patients with CRD without COVID-19, particularly nonrespiratory mortality. Contingency plans on continuing follow-up and monitoring of CRD patients are needed, ...

» Recovery and long-term health outcomes of SARS-CoV-2 infection in a prospective cohort in an urban setting, Kenya
29/05/25 20:00 from covid-19
CONCLUSIONS: Six months post-infection, half had lingering symptoms, with a third still affected after a year. Recovery was faster in younger, educated individuals, while severe long COVID was more common in women, those with low educati...

» Scope of rehabilitation for patients with long COVID symptoms in Bangladesh
29/05/25 20:00 from SARS-CoV-2 and Sars-Cov comparisons
CONCLUSION: Severity phenotypes can aid in the stratification of people with PCS for targeted therapies and rehabilitation care planning.

» Outcomes of surgical management in orbital cellulitis due to mucormycosis in patients recovered from COVID-19
29/05/25 20:00 from covid-19
CONCLUSION: In patients with orbital cellulitis secondary to mucormycosis, early surgical intervention under antifungal coverage may allow complete resolution of orbital mucormycosis, preventing vision loss, morbidity and mortality.

» Integrated transcriptomic analysis of COVID-19 stages and recovery: insights into key gene signatures, immune features, and diagnostic biomarkers through machine learning
29/05/25 20:00 from covid-19
CONCLUSION: This study identified CCR5, CYSLTR1, and KLRG1 as efficient diagnostic biomarkers for severe COVID-19 using machine learning and revealed immune regulatory features across COVID-19 progression and recovery.

» Psychometric Evaluation of the Thai Version of the Burdened Caregiver Scale for Schizophrenia and Co-occurring Methamphetamine Use: A Pilot Study
29/05/25 20:00 from covid-19
CONCLUSION: The TIBSCSM scale provides valuable insights for psychiatric nurses and mental health teams to measure the impact and burden experienced by caregivers of individuals with schizophrenia and methamphetamine use. It is particula...

» Factors Associated With Depression and Anxiety in People With Rare Diseases During COVID-19: A Cross-Sectional Study
29/05/25 20:00 from covid-19
Background: People living with a rare disease are a vulnerable patient group and experience challenges in participation and healthcare. Due to changes in healthcare and threat of the infection during coronavirus disease 2019 (COVID-19) p...

» Evidence of SARS-CoV-2 bacteriophage potential in human gut microbiota
29/05/25 20:00 from covid-19
CONCLUSIONS: Based on these results we conclude that, in addition to its well-documented interactions with eukaryotic cells, SARS-CoV-2 may act as a bacteriophage when interacting with at least two bacterial species known to be present i...

» Mu-opioid receptor expression on B cells as a potential biomarker for chronic pain: a follow-up study with patients with fibromyalgia
29/05/25 20:00 from covid-19
CONCLUSION: Mu-Lympho-Marker could be a promising marker for CP, as seen in FM cohort, and could be helpful for accurate diagnosis and tailored rehabilitation strategies. Further studies are needed to study MLM in CP of different aetiolo...

» Scaling up of electronic case-based disease surveillance reporting for COVID-19 and other notifiable diseases through capacity building and antigen RDT provision: a case study of Sierra Leone
29/05/25 20:00 from covid-19
CONCLUSION: The COVID-19 pandemic provided a unique opportunity for the country to scale up eCBDS in more health facilities, and this improved notification and investigation timelines. However, more still needs to be done to ensure count...

» Higher everyday functioning, lower quality of life, and home care are associated with persisting symptoms after a COVID-19 infection in German care recipients
29/05/25 20:00 from covid-19
INTRODUCTION: To date, risk factors for persisting symptoms after a COVID-19 infection have not been investigated in people needing care or support. Prior meta-analyses identified age, obesity, and female sex as risk factors for persisti...

» Influence of illness perception on depression and anxiety in individuals with schizophrenia during the COVID-19 pandemic
29/05/25 20:00 from covid-19
CONCLUSION: Illness perception concerning COVID-19 significantly influenced the severity of depression and anxiety in individuals with schizophrenia. Addressing these perceptions serves as an essential component of interventions aimed at...

» Unveiling sub-populations in critical care settings: a real-world data approach in COVID-19
29/05/25 20:00 from covid-19
CONCLUSION: By leveraging RWD and advanced clustering techniques, the study provides insights into the heterogeneity of COVID-19 presentations. The findings support the development of classification models that can inform more individual...

» Impact of guidance issued during COVID-19 to expand take-home doses of opioid agonist treatment (OAT) in Ireland: protocol for a population-based analysis of prescribing practices and patient outcomes 2018 to 2023
29/05/25 20:00 from covid-19
BACKGROUND: It is increasingly suggested that clinical guidelines and practices be updated to permanently expand relaxation around access to opioid agonist treatment (OAT) take-home doses after COVID-19. Despite a risk of OAT drug divers...

» Suppression of Monkeypox Virus by Downregulation of Fatty Acid Synthase and Upregulation of Cholesterol-25 Hydroxylase
29/05/25 20:00 from sars-cov-2
The World Health Organization declared the spread of monkeypox virus (MPXV) across multiple African countries a public health emergency of international concern in August 2024. This marks the second such declaration in the past 2 years i...

» Recovery and long-term health outcomes of SARS-CoV-2 infection in a prospective cohort in an urban setting, Kenya
29/05/25 20:00 from sars-cov-2
CONCLUSIONS: Six months post-infection, half had lingering symptoms, with a third still affected after a year. Recovery was faster in younger, educated individuals, while severe long COVID was more common in women, those with low educati...

» Evidence of SARS-CoV-2 bacteriophage potential in human gut microbiota
29/05/25 20:00 from sars-cov-2
CONCLUSIONS: Based on these results we conclude that, in addition to its well-documented interactions with eukaryotic cells, SARS-CoV-2 may act as a bacteriophage when interacting with at least two bacterial species known to be present i...

» Scaling up of electronic case-based disease surveillance reporting for COVID-19 and other notifiable diseases through capacity building and antigen RDT provision: a case study of Sierra Leone
29/05/25 20:00 from sars-cov-2
CONCLUSION: The COVID-19 pandemic provided a unique opportunity for the country to scale up eCBDS in more health facilities, and this improved notification and investigation timelines. However, more still needs to be done to ensure count...

» Platypnea-Orthodeoxia and Patent Foramen Ovale in a Patient in the Setting of COVID-19
29/05/25 20:00 from sars-cov-2
Platypnea-orthodeoxia syndrome is a rare condition characterized by positional dyspnea and hypoxemia, with symptoms presenting in the upright position and improving when recumbent. Hypoxemia in platypnea-orthodeoxia syndrome is defined a...

» COVID-19 disease outcomes in patients receiving clozapine versus other antipsychotics: a national study in Qatar
29/05/25 20:00 from sars-cov-2
CONCLUSION: Clozapine use was not associated with worse COVID-19 outcomes, supporting its relative safety during SARS-CoV-2 infection. These findings reassure clinicians regarding clozapine's continued use in treatment-resistant schizoph...

» Efficient non-parametric estimation of variable productivity Hawkes processes
29/05/25 20:00 from sars-cov-2
Several approaches to estimating the productivity function for a Hawkes point process with variable productivity are discussed, improved upon, and compared in terms of their root-mean-squared error and computational efficiency for variou...

» Granulomatous lymphocytic interstitial lung disease in common variable immune deficiency: an in-depth clinical, immunological, functional and radiological exploration with a focus on its management, challenged by chronic CMV infection
29/05/25 20:00 from sars-cov-2
BACKGROUND: Common variable immune deficiency (CVID) is the most prevalent inborn error of immunity (IEI), marked by diverse clinical-immunological phenotypes and significant immune-dysregulation, including granulomatous lymphocytic inte...

» The influence of the fourth industrial revolution in teaching and learning: the COVID-19 context
29/05/25 20:00 from sars-cov-2
CONCLUSIONS: Therefore, we recommended that the government and stakeholders within the education sector provide resources such as smart-boards, computers, and network access in schools lacking such facilities, as well as providing profes...

» Broad-spectrum coronavirus inhibitors discovered by modeling viral fusion dynamics
29/05/25 20:00 from sars-cov-2
Development of oral, broad-spectrum therapeutics targeting SARS-CoV-2, its variants, and related coronaviruses could curb the spread of COVID-19 and avert future pandemics. We created a novel computational discovery pipeline that employe...

» Scope of rehabilitation for patients with long COVID symptoms in Bangladesh
29/05/25 20:00 from sars-cov-2
CONCLUSION: Severity phenotypes can aid in the stratification of people with PCS for targeted therapies and rehabilitation care planning.

» Unraveling the Amplification-Free Quantitative Detection of Viral RNA in Nasopharyngeal Swab Samples Using a Compact Electrochemical Rapid Test Device
29/05/25 20:00 from sars-cov-2
Providing viral load numbers of infection events aids in the identification of disease severity and in the effective overall patient management. Gold-standard polymerase chain reaction (PCR) techniques make this possible but cannot be ap...

» SARS-CoV-2 Is Linked to Brain Volume Loss in Multiple Sclerosis
29/05/25 20:00 from sars-cov-2
OBJECTIVE: The impact of SARS-CoV-2 infection on brain and spinal cord pathology in patients with multiple sclerosis (pwMS) remains unclear. We aimed to describe changes in brain lesion activity and brain and spinal cord volumes followin...

» Pathological Glucose Levels Enhance Entry Factor Expression and Hepatic SARS-CoV-2 Infection
29/05/25 20:00 from sars-cov-2
Accumulating clinical evidence suggests an intricate relationship between severe COVID-19 and preexisting metabolic complications, which share some metabolic dysregulations, including hyperglycaemia, hyperinsulinaemia and hyperlipidaemia...

» The Indirect Impact of COVID-19 Pandemic on Mortality, Complications, and Healthcare Utilization Among Patients With Chronic Respiratory Diseases in Hong Kong: An Interrupted Time Series Analysis
29/05/25 20:00 from sars-cov-2
CONCLUSION: The disruption of usual healthcare impacts mortality rates among patients with CRD without COVID-19, particularly nonrespiratory mortality. Contingency plans on continuing follow-up and monitoring of CRD patients are needed, ...

» Adolescents Caught Between the Temptation and the Habit of Smoking
28/05/25 20:00 from Covid-19 origins
CONCLUSIONS: Tobacco consumption habits did not seem to be influenced by the new situation created by the COVID-19 pandemic. Regardless of gender, place of origin (rural or urban), or geographical region, the age at which the temptation ...

» Technostress Among Older Workers: A Central European Perspective
28/05/25 20:00 from Covid-19 origins
INTRODUCTION: This study explores the impact of two major labor market phenomena-the aging workforce and digitalization, which have global significance. The COVID-19 pandemic accelerated the adoption of digital technologies, resulting in...

» T-cell and antibody responses in immunocompromised patients with hematologic malignancies indicate strong potential of SARS-CoV-2 mRNA vaccines
28/05/25 20:00 from covid-19
Not available.

» Middle Cerebral Artery Dissection after AstraZeneca COVID-19 Vaccination
28/05/25 20:00 from covid-19
No abstract

» Heartache in the Heartland: Unraveling the Social Roots of Deaths of Despair in Kentucky
28/05/25 20:00 from covid-19
INTRODUCTION: Deaths of despair (DoD), encompassing suicides, drug overdoses, and alcohol-related liver diseases, have emerged as a critical public health crisis in the United States, with their rise particularly pronounced from 1995 to ...

» Time and Location: Physical Activity Trends in Parents and Children in a Rural Region During COVID-19
28/05/25 20:00 from covid-19
INTRODUCTION: COVID-19 restrictions altered the structure of the school and workday for families with children and led to changes in active transportation. Continued restrictions impacted access to many community locations and led to cha...

» Spinal cord metastasis in a long-term survivor of primary malignant glioblastoma: A case report
28/05/25 20:00 from covid-19
Glioblastoma (GBM) is the most common type of primary malignant brain tumor. Extracranial metastasis (ECM) is rare and usually indicates poor prognosis. We report a case of a 31-year-old female with GBM who underwent gross total resectio...

» Adolescents Caught Between the Temptation and the Habit of Smoking
28/05/25 20:00 from covid-19
CONCLUSIONS: Tobacco consumption habits did not seem to be influenced by the new situation created by the COVID-19 pandemic. Regardless of gender, place of origin (rural or urban), or geographical region, the age at which the temptation ...

» Post-coronavirus Disease 2019 (COVID-19) Cardiovascular Manifestations: A Systematic Review of Long-Term Risks and Outcomes
28/05/25 20:00 from covid-19
Emerging evidence suggests that coronavirus disease 2019 (COVID-19) survivors face increased risks of cardiovascular complications, but the long-term risks, underlying mechanisms, and clinical implications remain incompletely characteriz...

» Evaluating the knowledge, roles, and skills of health cadres in stunting prevention: A mixed-method study in Indonesia
28/05/25 20:00 from covid-19
CONCLUSION: There is a clear need to improve cadres' knowledge and skills, especially in anthropometric assessment. Recommendations include implementing certification-based training, introducing innovative and standardized measurement to...

» A qualitative study on the challenges of clinical leadership in an HIV care system: insights from healthcare providers in Eldoret, Kenya
28/05/25 20:00 from covid-19
CONCLUSION: The results provided important insights from the perspectives of healthcare providers. They show that in HIV care systems, clinical leaders are faced with diverse challenges that emerge from the supply, demand, and health sys...

» Mortality risk in patients with myasthenia gravis
28/05/25 20:00 from covid-19
INTRODUCTION: Although some reports link Myasthenia Gravis to higher mortality, the evidence remains contradictory and unclear. Real-life data is limited primarily due to challenges in selecting control groups and mitigating bias. Additi...

» Uso de inteligencia artificial en la predisposición genética a enfermedad crítica por COVID-19: evaluación comparativa de modelos de aprendizaje automático
28/05/25 20:00 from covid-19
CONCLUSIONES: Los modelos de aprendizaje automático pueden ayudar en la predicción por enfermedad crítica por Covid-19. La incorporación de SNPs asociados a gravedad a los datos clínicos y de laboratorio mejora el poder predictivo. Se re...

» Use of artificial intelligence to assess genetic predisposition to develop critical COVID-19 disease: a comparative study of machine learning models
28/05/25 20:00 from covid-19
CONCLUSIONS: Machine learning models may help predict progression into critical COVID-19-disease. The predictive power of models improves when SNPs associated with COVID-19 severity are integrated with laboratory and clinical data. Prior...

» Post-coronavirus Disease 2019 (COVID-19) Cardiovascular Manifestations: A Systematic Review of Long-Term Risks and Outcomes
28/05/25 20:00 from coronavirus
Emerging evidence suggests that coronavirus disease 2019 (COVID-19) survivors face increased risks of cardiovascular complications, but the long-term risks, underlying mechanisms, and clinical implications remain incompletely characteriz...

» Investigating Disaster Response Capability and Exploring Solutions to Improvement Response Process of Hospitals to the Infectious Diseases Pandemic: An Explanatory Sequential Mixed-Methods Study
28/05/25 20:00 from covid-19
CONCLUSION: Hospitals are vital in providing quality healthcare during emergencies. Lessons learned from our institution's response to the COVID-19 pandemic will guide more efficient services and preparedness for future emergencies. Give...

» The predictive role of inflammation indices derived from complete blood count in severe COVID-19 patients: a study from the United Arab Emirates
28/05/25 20:00 from covid-19
CONCLUSION: Identifying hematological markers' predictive effects and their cut-off values can aid healthcare providers in risk classification and the development of tailored treatment plans. It can also provide cheap, quick, and easy gu...

» Investigating Disaster Response Capability and Exploring Solutions to Improvement Response Process of Hospitals to the Infectious Diseases Pandemic: An Explanatory Sequential Mixed-Methods Study
28/05/25 20:00 from coronavirus
CONCLUSION: Hospitals are vital in providing quality healthcare during emergencies. Lessons learned from our institution's response to the COVID-19 pandemic will guide more efficient services and preparedness for future emergencies. Give...

» Technostress Among Older Workers: A Central European Perspective
28/05/25 20:00 from covid-19
INTRODUCTION: This study explores the impact of two major labor market phenomena-the aging workforce and digitalization, which have global significance. The COVID-19 pandemic accelerated the adoption of digital technologies, resulting in...

» Politics in Public Health: Growing Partisan Divides in COVID-19 Vaccine Attitudes and Uptake Post-2021 Presidential Inauguration
28/05/25 20:00 from coronavirus
CONCLUSION: The presidential transition appears to have widened partisan divides regrading COVID-19 vaccines. These findings highlight the need for depoliticized health messaging and bipartisan strategies to mitigate the influence of par...

» T-cell and antibody responses in immunocompromised patients with hematologic malignancies indicate strong potential of SARS-CoV-2 mRNA vaccines
28/05/25 20:00 from sars-cov-2
Not available.

» Immune modulation: the key to combat SARS-CoV-2 induced myocardial injury
28/05/25 20:00 from coronavirus
The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which caused the Coronavirus disease 2019 (COVID-19) pandemic, has posed significant healthcare challenges. In addition to respiratory complications, it has le...

» Nucleic acid vaccines: innovations, efficacy, and applications in at-risk populations
28/05/25 20:00 from coronavirus
For more than two centuries, the field of vaccine development has progressed through the adaptation of novel platforms in parallel with technological developments. Building off the advantages and shortcomings of first and second-generati...

» Exploring the respiratory viral landscape beyond influenza and SARS-CoV-2: a 2020-2023 study in Fujian, China
28/05/25 20:00 from coronavirus
INTRODUCTION: In this study, we investigated the local epidemiology and pathogen spectrum of acute respiratory infections caused by common respiratory viruses other than influenza virus (IFV) and severe acute respiratory syndrome coronav...

» Current status and influencing factors of knowledge, attitude and practice of personal protection of healthcare workers in isolation wards of COVID-19 designated hospitals
28/05/25 20:00 from coronavirus
CONCLUSION: In summary, for HCWs in isolation wards, increasing the frequency of protective training and reducing anxiety will improve their personal protection knowledge; alleviating depression will cultivate a positive attitude toward ...

» Post-coronavirus Disease 2019 (COVID-19) Cardiovascular Manifestations: A Systematic Review of Long-Term Risks and Outcomes
28/05/25 20:00 from sars-cov-2
Emerging evidence suggests that coronavirus disease 2019 (COVID-19) survivors face increased risks of cardiovascular complications, but the long-term risks, underlying mechanisms, and clinical implications remain incompletely characteriz...

» Using surveillance data to evaluate the effectiveness of inactivated/mRNA COVID-19 vaccine boosters in preventing fatal outcomes among severe COVID-19 cases during the current ambit of SARS-CoV-2 XBB and JN.1 variant circulation
28/05/25 20:00 from coronavirus
CONCLUSION: Vaccines based on ancestral strains maintain some degree of effectiveness against recently emerged variants, offering insights for healthcare policies in regions where earlier generations of inactivated and mRNA vaccines cont...

» Investigating Disaster Response Capability and Exploring Solutions to Improvement Response Process of Hospitals to the Infectious Diseases Pandemic: An Explanatory Sequential Mixed-Methods Study
28/05/25 20:00 from sars-cov-2
CONCLUSION: Hospitals are vital in providing quality healthcare during emergencies. Lessons learned from our institution's response to the COVID-19 pandemic will guide more efficient services and preparedness for future emergencies. Give...

» IoT and ML-driven framework for managing infectious disease risks in communal spaces: a post-COVID perspective
28/05/25 20:00 from coronavirus
COVID-19 has not only changed the way people live but has also altered the way all organizations operate. The most effective precautionary measure against the spread of the virus that caused the COVID-19 pandemic SARS-CoV-2, is to use fa...

» The "crossover effect" of COVID-19 in pregnancy on the infant microbiome
28/05/25 20:00 from sars-cov-2
CONCLUSION: COVID-19 during pregnancy can significantly compromise the establishment of the infant gut microbiome presumably by disrupting the mother's microbiome.

» Politics in Public Health: Growing Partisan Divides in COVID-19 Vaccine Attitudes and Uptake Post-2021 Presidential Inauguration
28/05/25 20:00 from sars-cov-2
CONCLUSION: The presidential transition appears to have widened partisan divides regrading COVID-19 vaccines. These findings highlight the need for depoliticized health messaging and bipartisan strategies to mitigate the influence of par...

» COVID-19-Associated Cytotoxic Lesions of the Corpus Callosum in Chinese Patients: A Retrospective Study
28/05/25 20:00 from coronavirus
CONCLUSIONS: Our study shows that CLOCCs associated with COVID-19 are characterized by a favorable prognosis and distinct MRI features, similar to those observed in other clinical contexts. This underscores the importance of including CL...

» Immune modulation: the key to combat SARS-CoV-2 induced myocardial injury
28/05/25 20:00 from sars-cov-2
The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which caused the Coronavirus disease 2019 (COVID-19) pandemic, has posed significant healthcare challenges. In addition to respiratory complications, it has le...

» Nucleic acid vaccines: innovations, efficacy, and applications in at-risk populations
28/05/25 20:00 from sars-cov-2
For more than two centuries, the field of vaccine development has progressed through the adaptation of novel platforms in parallel with technological developments. Building off the advantages and shortcomings of first and second-generati...

» Exploring the respiratory viral landscape beyond influenza and SARS-CoV-2: a 2020-2023 study in Fujian, China
28/05/25 20:00 from sars-cov-2
INTRODUCTION: In this study, we investigated the local epidemiology and pathogen spectrum of acute respiratory infections caused by common respiratory viruses other than influenza virus (IFV) and severe acute respiratory syndrome coronav...

» Current status and influencing factors of knowledge, attitude and practice of personal protection of healthcare workers in isolation wards of COVID-19 designated hospitals
28/05/25 20:00 from sars-cov-2
CONCLUSION: In summary, for HCWs in isolation wards, increasing the frequency of protective training and reducing anxiety will improve their personal protection knowledge; alleviating depression will cultivate a positive attitude toward ...

» Using surveillance data to evaluate the effectiveness of inactivated/mRNA COVID-19 vaccine boosters in preventing fatal outcomes among severe COVID-19 cases during the current ambit of SARS-CoV-2 XBB and JN.1 variant circulation
28/05/25 20:00 from sars-cov-2
CONCLUSION: Vaccines based on ancestral strains maintain some degree of effectiveness against recently emerged variants, offering insights for healthcare policies in regions where earlier generations of inactivated and mRNA vaccines cont...

» IoT and ML-driven framework for managing infectious disease risks in communal spaces: a post-COVID perspective
28/05/25 20:00 from sars-cov-2
COVID-19 has not only changed the way people live but has also altered the way all organizations operate. The most effective precautionary measure against the spread of the virus that caused the COVID-19 pandemic SARS-CoV-2, is to use fa...

» Influence of Steric and Electronic Properties of P2 Groups on Covalent Inhibitor Binding to SARS-CoV-2 Main Protease
28/05/25 20:00 from sars-cov-2
The main protease (MPro) of SARS-CoV-2 is a critical enzyme required for viral replication, making it a prime target for antiviral drug development. Covalent inhibitors, which form a stable interaction with the catalytic C145, have demon...

» COVID-19-Associated Cytotoxic Lesions of the Corpus Callosum in Chinese Patients: A Retrospective Study
28/05/25 20:00 from sars-cov-2
CONCLUSIONS: Our study shows that CLOCCs associated with COVID-19 are characterized by a favorable prognosis and distinct MRI features, similar to those observed in other clinical contexts. This underscores the importance of including CL...

» Update on the Epidemiology of Middle East Respiratory Syndrome Coronavirus - Worldwide, 2017-2023
28/05/25 20:00 from Coronavirus origins
Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus transmitted sporadically from camels to humans. Most reported human Middle East respiratory syndrome (MERS) cases have occurred in or near the Arabian Peninsula....

» Supporting authors of Ugandan young people living with HIV during the COVID-19 pandemic: A descriptive study
28/05/25 20:00 from covid-19
CONCLUSIONS: The study highlights age-related differences and psychosocial challenges for YPLHIV during the pandemic, emphasizing the need for targeted research and supportive interventions. Findings may guide future nursing, midwifery, ...

» Corrigendum to "Underlying health biases in previously-infected SARS-CoV-2 vaccination recipients: A cohort study" [J Infect 90 (2025) 106497]
28/05/25 20:00 from covid-19
No abstract

» Corrigendum to "Underlying health biases in previously-infected SARS-CoV-2 vaccination recipients: A cohort study" [J Infect 90 (2025) 106497]
28/05/25 20:00 from sars-cov-2
No abstract

» Tipranavir analogs as antiviral agents: Design, synthesis, in vitro, and in silico study of new SARS-CoV-2 main protease inhibitors
28/05/25 20:00 from covid-19
The current study aims at developing non-peptidic new antiviral hits against main protease (M^(pro)) of SARS-COV2 using the non-peptidic M^(pro) inhibitor tipranavir (TPV) as a starting point. In vitro protease inhibition assay of the ta...

» Tipranavir analogs as antiviral agents: Design, synthesis, in vitro, and in silico study of new SARS-CoV-2 main protease inhibitors
28/05/25 20:00 from sars-cov-2
The current study aims at developing non-peptidic new antiviral hits against main protease (M^(pro)) of SARS-COV2 using the non-peptidic M^(pro) inhibitor tipranavir (TPV) as a starting point. In vitro protease inhibition assay of the ta...

» COVID-19 vaccination and utility of booster dose: A community-based cross-sectional study
28/05/25 20:00 from sars-cov-2
CONCLUSION: While vaccination effectively increases antibody levels and reduces hospitalizations and severe outcomes, additional booster doses may offer limited benefits for the general population, as there appears to be a ceiling effect...

» Risk of Guillain-Barre syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A multinational self-controlled case series study
28/05/25 20:00 from sars-cov-2
CONCLUSION: In this large multinational study, we found increased risks of GBS within 42 days after Vaxzevria/Covishield vaccination or SARS-CoV-2 infection, and decreased risks after receiving Comirnaty/Tozinameran or CoronaVac/Sinovac ...

» COVID-19 vaccination and utility of booster dose: A community-based cross-sectional study
28/05/25 20:00 from covid-19
CONCLUSION: While vaccination effectively increases antibody levels and reduces hospitalizations and severe outcomes, additional booster doses may offer limited benefits for the general population, as there appears to be a ceiling effect...

» ACE2, a therapeutic target of COVID-19, needs to be treated with caution
28/05/25 20:00 from sars-cov-2 spike protein
Angiotensin-converting enzyme 2 (ACE2) has garnered significant attention for its crucial role in infection by both SARS-CoV and SARS-CoV-2. Consequently, it has emerged as a potential therapeutic target for treatment of COVID-19. It is ...

» Kawasaki disease in the pre- and post-COVID-19 era: shifts in patterns and outcomes from a multi-center study
28/05/25 20:00 from SARS-CoV-2 and Sars-Cov comparisons
CONCLUSIONS: Our study highlights shifts in the patterns of KD in the post-COVID-19 era. We observed a higher prevalence of incomplete KD cases over the 3 years following the pandemic.

» Long-term outcomes of patients with pre-existing coronary artery disease after SARS-CoV-2 infection
28/05/25 20:00 from sars-cov-2
BACKGROUND: The long-term outcomes of patients with pre-existing coronary artery disease (CAD) after SARS-CoV-2 infection are unknown.

» Risk of Guillain-Barre syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A multinational self-controlled case series study
28/05/25 20:00 from covid-19
CONCLUSION: In this large multinational study, we found increased risks of GBS within 42 days after Vaxzevria/Covishield vaccination or SARS-CoV-2 infection, and decreased risks after receiving Comirnaty/Tozinameran or CoronaVac/Sinovac ...

» Xuanfei Baidu Formula confers protection against viral pneumonia by modulating CD8⁺ T cell proliferation via MAPK signalling pathway
28/05/25 20:00 from sars-cov-2
CONCLUSION AND IMPLICATIONS: In conclusion, we found that XFBD regulates CD8^(+) T cell proliferation through the MAPK signaling pathway, thereby combating viral infection, which helps explain the theory and scientific principle of drug ...

» Tipranavir analogs as antiviral agents: Design, synthesis, in vitro, and in silico study of new SARS-CoV-2 main protease inhibitors
28/05/25 20:00 from coronavirus
The current study aims at developing non-peptidic new antiviral hits against main protease (M^(pro)) of SARS-COV2 using the non-peptidic M^(pro) inhibitor tipranavir (TPV) as a starting point. In vitro protease inhibition assay of the ta...

» Long-term outcomes of patients with pre-existing coronary artery disease after SARS-CoV-2 infection
28/05/25 20:00 from covid-19
BACKGROUND: The long-term outcomes of patients with pre-existing coronary artery disease (CAD) after SARS-CoV-2 infection are unknown.

» SARS-CoV-2 vaccination for individuals with schizophrenia in Ontario, Canada: A retrospective cohort study
28/05/25 20:00 from sars-cov-2
No abstract

» Update on the Epidemiology of Middle East Respiratory Syndrome Coronavirus - Worldwide, 2017-2023
28/05/25 20:00 from Covid-19 origins
Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus transmitted sporadically from camels to humans. Most reported human Middle East respiratory syndrome (MERS) cases have occurred in or near the Arabian Peninsula....

» Xuanfei Baidu Formula confers protection against viral pneumonia by modulating CD8⁺ T cell proliferation via MAPK signalling pathway
28/05/25 20:00 from covid-19
CONCLUSION AND IMPLICATIONS: In conclusion, we found that XFBD regulates CD8^(+) T cell proliferation through the MAPK signaling pathway, thereby combating viral infection, which helps explain the theory and scientific principle of drug ...

» Application of a high-resolution melt assay for monitoring SARS-CoV-2 variants in Burkina Faso and Kenya
28/05/25 20:00 from SARS-CoV-2 and Sars-Cov comparisons
The rapid emergence and global dissemination of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) highlighted a need for robust, adaptable surveillance systems. However, financial and infrastructure requirements for whole-geno...

» Childhood Humoral Immunity During and After COVID-19 Lockdowns
28/05/25 20:00 from sars-cov-2
Our study, including serum from 3678 hospital inpatients and outpatients sampled before, during and after the COVID-19 lockdown periods, showed a significant decrease in overall IgG levels during the periods of sanitary restriction, part...

» Xuanfei Baidu Formula confers protection against viral pneumonia by modulating CD8⁺ T cell proliferation via MAPK signalling pathway
28/05/25 20:00 from coronavirus
CONCLUSION AND IMPLICATIONS: In conclusion, we found that XFBD regulates CD8^(+) T cell proliferation through the MAPK signaling pathway, thereby combating viral infection, which helps explain the theory and scientific principle of drug ...

» Severity of COVID-19 in Hospitalized Immunocompromised Children Across Canada
28/05/25 20:00 from sars-cov-2
CONCLUSIONS: Hospitalized IC exhibited a lower risk of severe COVID-19 than non-IC, potentially reflecting lower admission thresholds for IC with respiratory infections.

» SARS-CoV-2 vaccination for individuals with schizophrenia in Ontario, Canada: A retrospective cohort study
28/05/25 20:00 from covid-19
No abstract

» Clinical Outcomes in Children <5 Years of Age Hospitalized for Respiratory Syncytial Virus, COVID-19 or Influenza in the United States
28/05/25 20:00 from coronavirus
CONCLUSION: Viral respiratory diseases cause a significant burden of illness in hospitalized children <5 years of age. Compared with COVID-19 and influenza, RSV had a significantly higher risk of nearly all inhospital outcomes examined. ...

» Respiratory viruses Ct values and association with clinical outcomes among adults visiting the ED with lower respiratory tract infections
28/05/25 20:00 from coronavirus
CONCLUSION: This study supports the association of higher Ct values with shorter LOS and lower mortality for SARS-CoV-2. In contrast, higher Ct values for influenza A were linked to longer LOS. Ct values were not predictive of ICU admiss...

» 'It's about the connections we've made with each other': resilience and risk translation in governing healthcare during the COVID-19 pandemic
28/05/25 20:00 from covid-19
In this paper we focus on risk translation in the governing of healthcare during the COVID-19 pandemic. We do so to explore crisis resilience in healthcare systems as a concrete practice. We build in this paper on a multi-sited ethnograp...

» Respiratory viruses Ct values and association with clinical outcomes among adults visiting the ED with lower respiratory tract infections
28/05/25 20:00 from sars-cov-2
CONCLUSION: This study supports the association of higher Ct values with shorter LOS and lower mortality for SARS-CoV-2. In contrast, higher Ct values for influenza A were linked to longer LOS. Ct values were not predictive of ICU admiss...

» Adolescents Caught Between the Temptation and the Habit of Smoking
28/05/25 20:00 from Covid-19 origins
CONCLUSIONS: Tobacco consumption habits did not seem to be influenced by the new situation created by the COVID-19 pandemic. Regardless of gender, place of origin (rural or urban), or geographical region, the age at which the temptation ...

» Nursing and Continuing Care Management Work Plan for People Living With COVID-19: Case Study of the Nakhon Pathom Province
28/05/25 20:00 from sars-cov-2
CONCLUSIONS: This research highlights the critical need for a proactive and comprehensive approach to managing post-COVID-19 care in Nakhon Pathom Province. By developing and implementing a database system for continuous monitoring and c...

» Clinical Outcomes in Children <5 Years of Age Hospitalized for Respiratory Syncytial Virus, COVID-19 or Influenza in the United States
28/05/25 20:00 from covid-19
CONCLUSION: Viral respiratory diseases cause a significant burden of illness in hospitalized children <5 years of age. Compared with COVID-19 and influenza, RSV had a significantly higher risk of nearly all inhospital outcomes examined. ...

» Nursing and Continuing Care Management Work Plan for People Living With COVID-19: Case Study of the Nakhon Pathom Province
28/05/25 20:00 from coronavirus
CONCLUSIONS: This research highlights the critical need for a proactive and comprehensive approach to managing post-COVID-19 care in Nakhon Pathom Province. By developing and implementing a database system for continuous monitoring and c...

» Technostress Among Older Workers: A Central European Perspective
28/05/25 20:00 from Covid-19 origins
INTRODUCTION: This study explores the impact of two major labor market phenomena-the aging workforce and digitalization, which have global significance. The COVID-19 pandemic accelerated the adoption of digital technologies, resulting in...

» The added diagnostic value of RT-PCR on faeces for the diagnosis of COVID-19
28/05/25 20:00 from coronavirus
CONCLUSIONS: We showed that adding SARS-CoV-2 RT-PCR on FS to URTS yields significantly more COVID-19 diagnoses. The inclusion of an FS may therefore be considered in patients with a negative URTS and high suspicion of COVID-19.

» Childhood Humoral Immunity During and After COVID-19 Lockdowns
28/05/25 20:00 from covid-19
Our study, including serum from 3678 hospital inpatients and outpatients sampled before, during and after the COVID-19 lockdown periods, showed a significant decrease in overall IgG levels during the periods of sanitary restriction, part...

» A Bioinspired Microfluidic Nucleic Acid Sensing Platform for Rapid and Simultaneous Screening of Viral Respiratory Infections
28/05/25 20:00 from sars-cov-2
In the postpandemic era, to tackle the engineering challenge from the concurrent outbreak of routine and emerging viral respiratory infections, microfluidic-chip-based point-of-care screening of multiple pathogens becomes essential for d...

» Severe Group A Streptococcus Infections in Children During and After the COVID-19 Pandemic: An Interrupted Time-series Analysis in Paris, France, 2018-2023
28/05/25 20:00 from covid-19
CONCLUSIONS: The late COVID-19 pandemic period was marked by a rise in both the incidence and severity of GAS infections. These findings may improve preparedness in future pandemics.

» Investigating post-COVID-19 confidence in emergency use authorization vaccines: A hypothetical case of mpox
28/05/25 20:00 from coronavirus
CONCLUSION: Findings underscore the importance of bolstering public trust in EUA vaccines, as well as addressing related attitudinal and behavioral factors, to enhance acceptance of mpox vaccines. This requires transparent communication ...

» The added diagnostic value of RT-PCR on faeces for the diagnosis of COVID-19
28/05/25 20:00 from sars-cov-2
CONCLUSIONS: We showed that adding SARS-CoV-2 RT-PCR on FS to URTS yields significantly more COVID-19 diagnoses. The inclusion of an FS may therefore be considered in patients with a negative URTS and high suspicion of COVID-19.

» 25 Years of Digital Health Toward Universal Health Coverage in Low- and Middle-Income Countries: Rapid Systematic Review
28/05/25 20:00 from covid-19
CONCLUSIONS: The future of digital health interventions in low- and middle-income countries holds immense promise, fueled by emerging technologies such as artificial intelligence, machine learning, and blockchain. However, challenges per...

» Update on the Epidemiology of Middle East Respiratory Syndrome Coronavirus - Worldwide, 2017-2023
28/05/25 20:00 from coronavirus
Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus transmitted sporadically from camels to humans. Most reported human Middle East respiratory syndrome (MERS) cases have occurred in or near the Arabian Peninsula....

» Investigating post-COVID-19 confidence in emergency use authorization vaccines: A hypothetical case of mpox
28/05/25 20:00 from sars-cov-2
CONCLUSION: Findings underscore the importance of bolstering public trust in EUA vaccines, as well as addressing related attitudinal and behavioral factors, to enhance acceptance of mpox vaccines. This requires transparent communication ...

» Validating a Patient-Reported Outcome Measure to Improve Emergency Department Asthma Care: Protocol for an Observational Study
28/05/25 20:00 from covid-19
CONCLUSIONS: Our study is intended to validate the use of PROMs during ED visits for acute asthma exacerbation among adult patients. Completion of the proposed aims will result in one of the first PROMs intended for use among adult ED pa...

» Kawasaki disease in the pre- and post-COVID-19 era: shifts in patterns and outcomes from a multi-center study
28/05/25 20:00 from coronavirus
CONCLUSIONS: Our study highlights shifts in the patterns of KD in the post-COVID-19 era. We observed a higher prevalence of incomplete KD cases over the 3 years following the pandemic.

» Kawasaki disease in the pre- and post-COVID-19 era: shifts in patterns and outcomes from a multi-center study
28/05/25 20:00 from sars-cov-2
CONCLUSIONS: Our study highlights shifts in the patterns of KD in the post-COVID-19 era. We observed a higher prevalence of incomplete KD cases over the 3 years following the pandemic.

» Severity of COVID-19 in Hospitalized Immunocompromised Children Across Canada
28/05/25 20:00 from covid-19
CONCLUSIONS: Hospitalized IC exhibited a lower risk of severe COVID-19 than non-IC, potentially reflecting lower admission thresholds for IC with respiratory infections.

» ACE2, a therapeutic target of COVID-19, needs to be treated with caution
28/05/25 20:00 from coronavirus
Angiotensin-converting enzyme 2 (ACE2) has garnered significant attention for its crucial role in infection by both SARS-CoV and SARS-CoV-2. Consequently, it has emerged as a potential therapeutic target for treatment of COVID-19. It is ...

» Public health system response to emerging infectious respiratory outbreaks in Iran
28/05/25 20:00 from coronavirus
CONCLUSIONS: The findings underscore the necessity for systemic reforms in Iran's public health framework to enhance preparedness for future pandemics. The realist approach provided insights into the complexities of intervention effectiv...

» Long-Term Clinical Outcomes of Adults Hospitalized for COVID-19 Pneumonia
28/05/25 20:00 from coronavirus
We conducted a multicenter, observational, 12-month follow-up study to identify the extended health burden of severe COVID-19 pneumonia by characterizing long-term sequelae of acute infection in participants previously enrolled in clinic...

» Application of a high-resolution melt assay for monitoring SARS-CoV-2 variants in Burkina Faso and Kenya
28/05/25 20:00 from coronavirus
The rapid emergence and global dissemination of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) highlighted a need for robust, adaptable surveillance systems. However, financial and infrastructure requirements for whole-geno...

» Midnolin inhibits coronavirus proliferation by degrading viral proteins
28/05/25 20:00 from coronavirus
Cells utilize proteasomes and selective autophagy to degrade ubiquitin-labeled viral proteins and inhibit viral proliferation. Midnolin, a midbrain nucleolar protein, is reported to use ubiquitin-independent proteasomal degradation to de...

» Perirenal hemorrhage associated with feline infectious peritonitis: a novel presentation of a classic disease
28/05/25 20:00 from coronavirus
Feline infectious peritonitis (FIP), caused by a mutated biotype of feline coronavirus (FCoV; Coronaviridae, Alphacoronavirus), is a significant disease of felids. We investigated perirenal hemorrhage, an unreported lesion in FIP, throug...

» Update on the Epidemiology of Middle East Respiratory Syndrome Coronavirus - Worldwide, 2017-2023
28/05/25 20:00 from Covid-19 origins
Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus transmitted sporadically from camels to humans. Most reported human Middle East respiratory syndrome (MERS) cases have occurred in or near the Arabian Peninsula....

» COVID-19 disease severity in language minorities in Finland: an observational population-based register study
28/05/25 20:00 from sars-cov-2
CONCLUSIONS: CRP and leukocyte count were the most reliable indicators of more severe COVID-19 disease presentation and ICU admission. Although those with a foreign first language were overrepresented in COVID-19 related hospitalizations...

» Update on the Epidemiology of Middle East Respiratory Syndrome Coronavirus - Worldwide, 2017-2023
28/05/25 20:00 from Coronavirus origins
Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus transmitted sporadically from camels to humans. Most reported human Middle East respiratory syndrome (MERS) cases have occurred in or near the Arabian Peninsula....

» Managing withdrawals and exclusions of study participants in COVID-19-research by NUKLEUS
28/05/25 20:00 from sars-cov-2
CONCLUSIONS: This manuscript is to the author's knowledge one of the first article related to withdrawals within COVID-19-studies (NAPKON). The processes serve as 'best practice' examples for planning and establishing withdrawal processe...

» Adolescents Caught Between the Temptation and the Habit of Smoking
28/05/25 20:00 from Covid-19 origins
CONCLUSIONS: Tobacco consumption habits did not seem to be influenced by the new situation created by the COVID-19 pandemic. Regardless of gender, place of origin (rural or urban), or geographical region, the age at which the temptation ...

» Did COVID-19 surveillance system sensitivity change after Omicron? a retrospective observational study in England
28/05/25 20:00 from sars-cov-2
CONCLUSIONS: From September 2021 to June 2022, complementary SS generally reflected case rises and falls. Ascertainment was highest in the Delta-dominant period but no complementary tracker was highly stable. Factors other than which var...

» Technostress Among Older Workers: A Central European Perspective
28/05/25 20:00 from Covid-19 origins
INTRODUCTION: This study explores the impact of two major labor market phenomena-the aging workforce and digitalization, which have global significance. The COVID-19 pandemic accelerated the adoption of digital technologies, resulting in...

» Characteristics of SARS-CoV-2 variants and potential co-infected pathogens in hospitalized patients based on metagenomic next-generation sequencing
28/05/25 20:00 from sars-cov-2
Metagenomic next-generation sequencing (mNGS) is widely used to diagnose complex infections in hospitalized patients, particularly those associated with COVID-19 which has garnered significant concern over the past five years. To investi...

» Evaluation of combined BCG and SARS-CoV-2 vaccination for immune enhancement and lung protection in Syrian hamsters
28/05/25 20:00 from sars-cov-2
SARS-CoV-2 (SCV2) has posed significant global challenges, necessitating improved immunization strategies to enhance protection and mitigate disease severity. Combining Bacille Calmette-Guérin (BCG) with SCV2 vaccine shows potential due ...

» ACE2, a therapeutic target of COVID-19, needs to be treated with caution
28/05/25 20:00 from sars-cov-2 spike protein
Angiotensin-converting enzyme 2 (ACE2) has garnered significant attention for its crucial role in infection by both SARS-CoV and SARS-CoV-2. Consequently, it has emerged as a potential therapeutic target for treatment of COVID-19. It is ...

» Addressing international research challenges in child and adolescent mental health during global crises: experience and recommendations of the Co-SPACE international consortium
28/05/25 20:00 from covid-19
No abstract

» COVID-19 disease severity in language minorities in Finland: an observational population-based register study
28/05/25 20:00 from coronavirus
CONCLUSIONS: CRP and leukocyte count were the most reliable indicators of more severe COVID-19 disease presentation and ICU admission. Although those with a foreign first language were overrepresented in COVID-19 related hospitalizations...

» Kawasaki disease in the pre- and post-COVID-19 era: shifts in patterns and outcomes from a multi-center study
28/05/25 20:00 from SARS-CoV-2 and Sars-Cov comparisons
CONCLUSIONS: Our study highlights shifts in the patterns of KD in the post-COVID-19 era. We observed a higher prevalence of incomplete KD cases over the 3 years following the pandemic.

» Development of bivalent RBD adapted COVID-19 vaccines for broad sarbecovirus immunity
28/05/25 20:00 from sars-cov-2
COVID-19 vaccine adaptation is critical to respond to continuously emerging SARS-CoV-2 variants with enhanced immune evasion. The ARVAC protein subunit vaccine, based on the receptor binding domain of the spike protein of SARS-CoV-2, has...

» A chronicle of crises and emergencies: (dis)continuity of care for Syrian refugee children with neglected non-communicable diseases in Lebanon
28/05/25 20:00 from covid-19
Lebanon's recent history has been marked by intersecting crises, including a severe economic collapse, the Beirut port explosion, and the COVID-19 pandemic. Amidst this "polycrisis," the healthcare system has become increasingly reliant ...

» Changes and continuities in undergraduate nursing education during and after COVID-19: a European comparative study from the perspective of health science
28/05/25 20:00 from covid-19
CONCLUSIONS: The COVID-19 pandemic has widened the gap between university-educated nurses and the clinical setting, i.e. between theory and practise, underlining the importance of HSS in nursing education. Rebuilding strong partnerships ...

» COVID-19 disease severity in language minorities in Finland: an observational population-based register study
28/05/25 20:00 from covid-19
CONCLUSIONS: CRP and leukocyte count were the most reliable indicators of more severe COVID-19 disease presentation and ICU admission. Although those with a foreign first language were overrepresented in COVID-19 related hospitalizations...

» Did COVID-19 surveillance system sensitivity change after Omicron? a retrospective observational study in England
28/05/25 20:00 from coronavirus
CONCLUSIONS: From September 2021 to June 2022, complementary SS generally reflected case rises and falls. Ascertainment was highest in the Delta-dominant period but no complementary tracker was highly stable. Factors other than which var...

» Drug treatments for mild or moderate covid-19: systematic review and network meta-analysis
28/05/25 20:00 from sars-cov-2
CONCLUSION: Nirmatrelvir-ritonavir and remdesivir probably reduce admission to hospital, and systemic corticosteroids and molnupiravir may reduce admission to hospital. Several medications including systemic corticosteroids and molnupira...

» Managing withdrawals and exclusions of study participants in COVID-19-research by NUKLEUS
28/05/25 20:00 from covid-19
CONCLUSIONS: This manuscript is to the author's knowledge one of the first article related to withdrawals within COVID-19-studies (NAPKON). The processes serve as 'best practice' examples for planning and establishing withdrawal processe...

» A transcriptome-based human universal senescence index (hUSI) robustly predicts cellular senescence under various conditions
28/05/25 20:00 from coronavirus
Despite the manifestation and contribution of cellular senescence to aging and various diseases, accurate identification of heterogeneous senescent cells remains challenging. Current senescence evaluation methods rely mainly on limited m...

» Serum antineuronal antibodies in patients with post-COVID-19 condition - association to intensive care
28/05/25 20:00 from sars-cov-2
Post-COVID-19 condition (PCC), characterized by persistent symptoms following SARS-CoV-2 infection, is a global health challenge. Neurological symptoms are common in PCC, and immune-mediated mechanisms have been proposed as potential con...

» Did COVID-19 surveillance system sensitivity change after Omicron? a retrospective observational study in England
28/05/25 20:00 from covid-19
CONCLUSIONS: From September 2021 to June 2022, complementary SS generally reflected case rises and falls. Ascertainment was highest in the Delta-dominant period but no complementary tracker was highly stable. Factors other than which var...

» Application of a high-resolution melt assay for monitoring SARS-CoV-2 variants in Burkina Faso and Kenya
28/05/25 20:00 from SARS-CoV-2 and Sars-Cov comparisons
The rapid emergence and global dissemination of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) highlighted a need for robust, adaptable surveillance systems. However, financial and infrastructure requirements for whole-geno...

» Characteristics of SARS-CoV-2 variants and potential co-infected pathogens in hospitalized patients based on metagenomic next-generation sequencing
28/05/25 20:00 from coronavirus
Metagenomic next-generation sequencing (mNGS) is widely used to diagnose complex infections in hospitalized patients, particularly those associated with COVID-19 which has garnered significant concern over the past five years. To investi...

» Chitosan and mannose-modified dual-functional mRNA-LNP vaccines for robust systemic and mucosal immune responses
28/05/25 20:00 from sars-cov-2
Mucosal vaccination plays a crucial role in activating frontline immune responses, preventing infection and transmission of respiratory pathogens. However, the development of effective mRNA mucosal vaccines faces multiple challenges, inc...

» Evaluation of combined BCG and SARS-CoV-2 vaccination for immune enhancement and lung protection in Syrian hamsters
28/05/25 20:00 from coronavirus
SARS-CoV-2 (SCV2) has posed significant global challenges, necessitating improved immunization strategies to enhance protection and mitigate disease severity. Combining Bacille Calmette-Guérin (BCG) with SCV2 vaccine shows potential due ...

» The effect of outcome choice on vaccine dose allocation: a modelling study
28/05/25 20:00 from sars-cov-2
CONCLUSIONS: Rather than focussing on deaths, which is the approach taken in many existing COVID-19 models, targeting life-years can lead to different vaccination policies being considered optimal. We argue that - alongside infections, h...

» Analyzing the Interplay of Air Pollution and COVID-19: A Review on Health Implications
28/05/25 20:00 from covid-19
The COVID-19 pandemic has had a profound impact on global public health, highlighting the complex relationship between air pollution and disease transmission. Approximately 2.3 billion people live in regions with high levels of air pollu...

» Unravelling the mechanism of action of Huashibaidu formula volatile metabolome for the treatment of COVID-19 and its mutants from the perspectives of network pharmacology and molecular docking
28/05/25 20:00 from sars-cov-2
CONCLUSIONS: This study revealed that the HSBD formula not only had a therapeutic effect on the initial SARS-CoV-2, but also had a restraining effect on the virus subtypes. This article gives a basic theory for the treatment of COVID-19 ...

» Serum proteomic approach to identifying differentially expressed proteins in effusive feline infectious peritonitis
28/05/25 20:00 from coronavirus
Feline infectious peritonitis (FIP) is a lethal, viral-induced immune-mediated disease that remains a challenge for diagnosis and treatment in cats. Proteomic profiling, which analyzes the protein content of biological samples, offers th...

» Functional outcomes among the survivors of veno-venous extracorporeal membrane oxygenation during the COVID-19 pandemic: a historical cohort study
28/05/25 20:00 from covid-19
CONCLUSIONS: Patients who required VV-ECMO experienced significant functional disability, pain, cognitive challenges, mental health problems, and lower quality of life approximately two years after discharge.

» A transcriptome-based human universal senescence index (hUSI) robustly predicts cellular senescence under various conditions
28/05/25 20:00 from covid-19
Despite the manifestation and contribution of cellular senescence to aging and various diseases, accurate identification of heterogeneous senescent cells remains challenging. Current senescence evaluation methods rely mainly on limited m...

» Corrigendum to "Underlying health biases in previously-infected SARS-CoV-2 vaccination recipients: A cohort study" [J Infect 90 (2025) 106497]
28/05/25 20:00 from sars-cov-2
No abstract

» Whole-Body [¹⁸F]DPA-714 Kinetic Assessment Using PET/CT Scanner with Long Axial Field of View
28/05/25 20:00 from coronavirus
Multisystemic inflammation might be a key pathophysiologic mechanism in post-coronavirus disease 2019 (post-COVID) syndrome. N,N-diethyl-2-(2-(4-(2-fluoroethoxy)phenyl)5,7dimethylpyrazolo[1,5a] pyrimidin-3-yl)acetamide ([^(18)F]DPA-714),...

» Characteristics of SARS-CoV-2 variants and potential co-infected pathogens in hospitalized patients based on metagenomic next-generation sequencing
28/05/25 20:00 from covid-19
Metagenomic next-generation sequencing (mNGS) is widely used to diagnose complex infections in hospitalized patients, particularly those associated with COVID-19 which has garnered significant concern over the past five years. To investi...

» Tipranavir analogs as antiviral agents: Design, synthesis, in vitro, and in silico study of new SARS-CoV-2 main protease inhibitors
28/05/25 20:00 from sars-cov-2
The current study aims at developing non-peptidic new antiviral hits against main protease (M^(pro)) of SARS-COV2 using the non-peptidic M^(pro) inhibitor tipranavir (TPV) as a starting point. In vitro protease inhibition assay of the ta...

» Evaluation of combined BCG and SARS-CoV-2 vaccination for immune enhancement and lung protection in Syrian hamsters
28/05/25 20:00 from covid-19
SARS-CoV-2 (SCV2) has posed significant global challenges, necessitating improved immunization strategies to enhance protection and mitigate disease severity. Combining Bacille Calmette-Guérin (BCG) with SCV2 vaccine shows potential due ...

» Drug treatments for mild or moderate covid-19: systematic review and network meta-analysis
28/05/25 20:00 from coronavirus
CONCLUSION: Nirmatrelvir-ritonavir and remdesivir probably reduce admission to hospital, and systemic corticosteroids and molnupiravir may reduce admission to hospital. Several medications including systemic corticosteroids and molnupira...

» COVID-19 vaccination and utility of booster dose: A community-based cross-sectional study
28/05/25 20:00 from sars-cov-2
CONCLUSION: While vaccination effectively increases antibody levels and reduces hospitalizations and severe outcomes, additional booster doses may offer limited benefits for the general population, as there appears to be a ceiling effect...

» Serum proteomic approach to identifying differentially expressed proteins in effusive feline infectious peritonitis
28/05/25 20:00 from covid-19
Feline infectious peritonitis (FIP) is a lethal, viral-induced immune-mediated disease that remains a challenge for diagnosis and treatment in cats. Proteomic profiling, which analyzes the protein content of biological samples, offers th...

» Mechanism and biological significance of erythrocyte homoaggregation (rouleaux formation): temperature-dependent entropic liberation of water from cells and macromolecules
28/05/25 20:00 from coronavirus
In the pre-antibiotic era, infections were usually more frequent and serious than today. Robin Fåhraeus (1888-1958) examined the erythrocyte sedimentation rate (ESR) test for infections, which was normally carried out in vitro with fresh...

» Risk of Guillain-Barre syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A multinational self-controlled case series study
28/05/25 20:00 from sars-cov-2
CONCLUSION: In this large multinational study, we found increased risks of GBS within 42 days after Vaxzevria/Covishield vaccination or SARS-CoV-2 infection, and decreased risks after receiving Comirnaty/Tozinameran or CoronaVac/Sinovac ...

» Development of bivalent RBD adapted COVID-19 vaccines for broad sarbecovirus immunity
28/05/25 20:00 from covid-19
COVID-19 vaccine adaptation is critical to respond to continuously emerging SARS-CoV-2 variants with enhanced immune evasion. The ARVAC protein subunit vaccine, based on the receptor binding domain of the spike protein of SARS-CoV-2, has...

» Unravelling the mechanism of action of Huashibaidu formula volatile metabolome for the treatment of COVID-19 and its mutants from the perspectives of network pharmacology and molecular docking
28/05/25 20:00 from coronavirus
CONCLUSIONS: This study revealed that the HSBD formula not only had a therapeutic effect on the initial SARS-CoV-2, but also had a restraining effect on the virus subtypes. This article gives a basic theory for the treatment of COVID-19 ...

» Tipranavir analogs as antiviral agents: Design, synthesis, in vitro, and in silico study of new SARS-CoV-2 main protease inhibitors
28/05/25 20:00 from coronavirus
The current study aims at developing non-peptidic new antiviral hits against main protease (M^(pro)) of SARS-COV2 using the non-peptidic M^(pro) inhibitor tipranavir (TPV) as a starting point. In vitro protease inhibition assay of the ta...

» Xuanfei Baidu Formula confers protection against viral pneumonia by modulating CD8⁺ T cell proliferation via MAPK signalling pathway
28/05/25 20:00 from coronavirus
CONCLUSION AND IMPLICATIONS: In conclusion, we found that XFBD regulates CD8^(+) T cell proliferation through the MAPK signaling pathway, thereby combating viral infection, which helps explain the theory and scientific principle of drug ...

» Clinical Outcomes in Children <5 Years of Age Hospitalized for Respiratory Syncytial Virus, COVID-19 or Influenza in the United States
28/05/25 20:00 from coronavirus
CONCLUSION: Viral respiratory diseases cause a significant burden of illness in hospitalized children <5 years of age. Compared with COVID-19 and influenza, RSV had a significantly higher risk of nearly all inhospital outcomes examined. ...

» Update on the Epidemiology of Middle East Respiratory Syndrome Coronavirus - Worldwide, 2017-2023
28/05/25 20:00 from Coronavirus origins
Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus transmitted sporadically from camels to humans. Most reported human Middle East respiratory syndrome (MERS) cases have occurred in or near the Arabian Peninsula....

» Update on the Epidemiology of Middle East Respiratory Syndrome Coronavirus - Worldwide, 2017-2023
28/05/25 20:00 from Covid-19 origins
Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus transmitted sporadically from camels to humans. Most reported human Middle East respiratory syndrome (MERS) cases have occurred in or near the Arabian Peninsula....

» Adolescents Caught Between the Temptation and the Habit of Smoking
28/05/25 20:00 from Covid-19 origins
CONCLUSIONS: Tobacco consumption habits did not seem to be influenced by the new situation created by the COVID-19 pandemic. Regardless of gender, place of origin (rural or urban), or geographical region, the age at which the temptation ...

» Technostress Among Older Workers: A Central European Perspective
28/05/25 20:00 from Covid-19 origins
INTRODUCTION: This study explores the impact of two major labor market phenomena-the aging workforce and digitalization, which have global significance. The COVID-19 pandemic accelerated the adoption of digital technologies, resulting in...

» Addressing international research challenges in child and adolescent mental health during global crises: experience and recommendations of the Co-SPACE international consortium
28/05/25 20:00 from covid-19
No abstract

» A chronicle of crises and emergencies: (dis)continuity of care for Syrian refugee children with neglected non-communicable diseases in Lebanon
28/05/25 20:00 from covid-19
Lebanon's recent history has been marked by intersecting crises, including a severe economic collapse, the Beirut port explosion, and the COVID-19 pandemic. Amidst this "polycrisis," the healthcare system has become increasingly reliant ...

» ACE2, a therapeutic target of COVID-19, needs to be treated with caution
28/05/25 20:00 from sars-cov-2 spike protein
Angiotensin-converting enzyme 2 (ACE2) has garnered significant attention for its crucial role in infection by both SARS-CoV and SARS-CoV-2. Consequently, it has emerged as a potential therapeutic target for treatment of COVID-19. It is ...

» Changes and continuities in undergraduate nursing education during and after COVID-19: a European comparative study from the perspective of health science
28/05/25 20:00 from covid-19
CONCLUSIONS: The COVID-19 pandemic has widened the gap between university-educated nurses and the clinical setting, i.e. between theory and practise, underlining the importance of HSS in nursing education. Rebuilding strong partnerships ...

» COVID-19 disease severity in language minorities in Finland: an observational population-based register study
28/05/25 20:00 from covid-19
CONCLUSIONS: CRP and leukocyte count were the most reliable indicators of more severe COVID-19 disease presentation and ICU admission. Although those with a foreign first language were overrepresented in COVID-19 related hospitalizations...

» Managing withdrawals and exclusions of study participants in COVID-19-research by NUKLEUS
28/05/25 20:00 from covid-19
CONCLUSIONS: This manuscript is to the author's knowledge one of the first article related to withdrawals within COVID-19-studies (NAPKON). The processes serve as 'best practice' examples for planning and establishing withdrawal processe...

» COVID-19 disease severity in language minorities in Finland: an observational population-based register study
28/05/25 20:00 from sars-cov-2
CONCLUSIONS: CRP and leukocyte count were the most reliable indicators of more severe COVID-19 disease presentation and ICU admission. Although those with a foreign first language were overrepresented in COVID-19 related hospitalizations...

» Did COVID-19 surveillance system sensitivity change after Omicron? a retrospective observational study in England
28/05/25 20:00 from covid-19
CONCLUSIONS: From September 2021 to June 2022, complementary SS generally reflected case rises and falls. Ascertainment was highest in the Delta-dominant period but no complementary tracker was highly stable. Factors other than which var...

» Analyzing the Interplay of Air Pollution and COVID-19: A Review on Health Implications
28/05/25 20:00 from covid-19
The COVID-19 pandemic has had a profound impact on global public health, highlighting the complex relationship between air pollution and disease transmission. Approximately 2.3 billion people live in regions with high levels of air pollu...

» Managing withdrawals and exclusions of study participants in COVID-19-research by NUKLEUS
28/05/25 20:00 from sars-cov-2
CONCLUSIONS: This manuscript is to the author's knowledge one of the first article related to withdrawals within COVID-19-studies (NAPKON). The processes serve as 'best practice' examples for planning and establishing withdrawal processe...

» Kawasaki disease in the pre- and post-COVID-19 era: shifts in patterns and outcomes from a multi-center study
28/05/25 20:00 from SARS-CoV-2 and Sars-Cov comparisons
CONCLUSIONS: Our study highlights shifts in the patterns of KD in the post-COVID-19 era. We observed a higher prevalence of incomplete KD cases over the 3 years following the pandemic.

» Functional outcomes among the survivors of veno-venous extracorporeal membrane oxygenation during the COVID-19 pandemic: a historical cohort study
28/05/25 20:00 from covid-19
CONCLUSIONS: Patients who required VV-ECMO experienced significant functional disability, pain, cognitive challenges, mental health problems, and lower quality of life approximately two years after discharge.

» Did COVID-19 surveillance system sensitivity change after Omicron? a retrospective observational study in England
28/05/25 20:00 from sars-cov-2
CONCLUSIONS: From September 2021 to June 2022, complementary SS generally reflected case rises and falls. Ascertainment was highest in the Delta-dominant period but no complementary tracker was highly stable. Factors other than which var...

» A transcriptome-based human universal senescence index (hUSI) robustly predicts cellular senescence under various conditions
28/05/25 20:00 from covid-19
Despite the manifestation and contribution of cellular senescence to aging and various diseases, accurate identification of heterogeneous senescent cells remains challenging. Current senescence evaluation methods rely mainly on limited m...

» Characteristics of SARS-CoV-2 variants and potential co-infected pathogens in hospitalized patients based on metagenomic next-generation sequencing
28/05/25 20:00 from covid-19
Metagenomic next-generation sequencing (mNGS) is widely used to diagnose complex infections in hospitalized patients, particularly those associated with COVID-19 which has garnered significant concern over the past five years. To investi...

» Application of a high-resolution melt assay for monitoring SARS-CoV-2 variants in Burkina Faso and Kenya
28/05/25 20:00 from SARS-CoV-2 and Sars-Cov comparisons
The rapid emergence and global dissemination of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) highlighted a need for robust, adaptable surveillance systems. However, financial and infrastructure requirements for whole-geno...

» Characteristics of SARS-CoV-2 variants and potential co-infected pathogens in hospitalized patients based on metagenomic next-generation sequencing
28/05/25 20:00 from sars-cov-2
Metagenomic next-generation sequencing (mNGS) is widely used to diagnose complex infections in hospitalized patients, particularly those associated with COVID-19 which has garnered significant concern over the past five years. To investi...

» Evaluation of combined BCG and SARS-CoV-2 vaccination for immune enhancement and lung protection in Syrian hamsters
28/05/25 20:00 from sars-cov-2
SARS-CoV-2 (SCV2) has posed significant global challenges, necessitating improved immunization strategies to enhance protection and mitigate disease severity. Combining Bacille Calmette-Guérin (BCG) with SCV2 vaccine shows potential due ...

» Development of bivalent RBD adapted COVID-19 vaccines for broad sarbecovirus immunity
28/05/25 20:00 from sars-cov-2
COVID-19 vaccine adaptation is critical to respond to continuously emerging SARS-CoV-2 variants with enhanced immune evasion. The ARVAC protein subunit vaccine, based on the receptor binding domain of the spike protein of SARS-CoV-2, has...

» Drug treatments for mild or moderate covid-19: systematic review and network meta-analysis
28/05/25 20:00 from sars-cov-2
CONCLUSION: Nirmatrelvir-ritonavir and remdesivir probably reduce admission to hospital, and systemic corticosteroids and molnupiravir may reduce admission to hospital. Several medications including systemic corticosteroids and molnupira...

» Evaluation of combined BCG and SARS-CoV-2 vaccination for immune enhancement and lung protection in Syrian hamsters
28/05/25 20:00 from covid-19
SARS-CoV-2 (SCV2) has posed significant global challenges, necessitating improved immunization strategies to enhance protection and mitigate disease severity. Combining Bacille Calmette-Guérin (BCG) with SCV2 vaccine shows potential due ...

» Serum antineuronal antibodies in patients with post-COVID-19 condition - association to intensive care
28/05/25 20:00 from sars-cov-2
Post-COVID-19 condition (PCC), characterized by persistent symptoms following SARS-CoV-2 infection, is a global health challenge. Neurological symptoms are common in PCC, and immune-mediated mechanisms have been proposed as potential con...

» Serum proteomic approach to identifying differentially expressed proteins in effusive feline infectious peritonitis
28/05/25 20:00 from covid-19
Feline infectious peritonitis (FIP) is a lethal, viral-induced immune-mediated disease that remains a challenge for diagnosis and treatment in cats. Proteomic profiling, which analyzes the protein content of biological samples, offers th...

» COVID-19 disease severity in language minorities in Finland: an observational population-based register study
28/05/25 20:00 from coronavirus
CONCLUSIONS: CRP and leukocyte count were the most reliable indicators of more severe COVID-19 disease presentation and ICU admission. Although those with a foreign first language were overrepresented in COVID-19 related hospitalizations...

» Development of bivalent RBD adapted COVID-19 vaccines for broad sarbecovirus immunity
28/05/25 20:00 from covid-19
COVID-19 vaccine adaptation is critical to respond to continuously emerging SARS-CoV-2 variants with enhanced immune evasion. The ARVAC protein subunit vaccine, based on the receptor binding domain of the spike protein of SARS-CoV-2, has...

» Chitosan and mannose-modified dual-functional mRNA-LNP vaccines for robust systemic and mucosal immune responses
28/05/25 20:00 from sars-cov-2
Mucosal vaccination plays a crucial role in activating frontline immune responses, preventing infection and transmission of respiratory pathogens. However, the development of effective mRNA mucosal vaccines faces multiple challenges, inc...

» Did COVID-19 surveillance system sensitivity change after Omicron? a retrospective observational study in England
28/05/25 20:00 from coronavirus
CONCLUSIONS: From September 2021 to June 2022, complementary SS generally reflected case rises and falls. Ascertainment was highest in the Delta-dominant period but no complementary tracker was highly stable. Factors other than which var...

» The effect of outcome choice on vaccine dose allocation: a modelling study
28/05/25 20:00 from sars-cov-2
CONCLUSIONS: Rather than focussing on deaths, which is the approach taken in many existing COVID-19 models, targeting life-years can lead to different vaccination policies being considered optimal. We argue that - alongside infections, h...

» A transcriptome-based human universal senescence index (hUSI) robustly predicts cellular senescence under various conditions
28/05/25 20:00 from coronavirus
Despite the manifestation and contribution of cellular senescence to aging and various diseases, accurate identification of heterogeneous senescent cells remains challenging. Current senescence evaluation methods rely mainly on limited m...

» Unravelling the mechanism of action of Huashibaidu formula volatile metabolome for the treatment of COVID-19 and its mutants from the perspectives of network pharmacology and molecular docking
28/05/25 20:00 from sars-cov-2
CONCLUSIONS: This study revealed that the HSBD formula not only had a therapeutic effect on the initial SARS-CoV-2, but also had a restraining effect on the virus subtypes. This article gives a basic theory for the treatment of COVID-19 ...

» Corrigendum to "Underlying health biases in previously-infected SARS-CoV-2 vaccination recipients: A cohort study" [J Infect 90 (2025) 106497]
28/05/25 20:00 from sars-cov-2
No abstract

» Characteristics of SARS-CoV-2 variants and potential co-infected pathogens in hospitalized patients based on metagenomic next-generation sequencing
28/05/25 20:00 from coronavirus
Metagenomic next-generation sequencing (mNGS) is widely used to diagnose complex infections in hospitalized patients, particularly those associated with COVID-19 which has garnered significant concern over the past five years. To investi...

» Tipranavir analogs as antiviral agents: Design, synthesis, in vitro, and in silico study of new SARS-CoV-2 main protease inhibitors
28/05/25 20:00 from sars-cov-2
The current study aims at developing non-peptidic new antiviral hits against main protease (M^(pro)) of SARS-COV2 using the non-peptidic M^(pro) inhibitor tipranavir (TPV) as a starting point. In vitro protease inhibition assay of the ta...

» COVID-19 vaccination and utility of booster dose: A community-based cross-sectional study
28/05/25 20:00 from sars-cov-2
CONCLUSION: While vaccination effectively increases antibody levels and reduces hospitalizations and severe outcomes, additional booster doses may offer limited benefits for the general population, as there appears to be a ceiling effect...

» Evaluation of combined BCG and SARS-CoV-2 vaccination for immune enhancement and lung protection in Syrian hamsters
28/05/25 20:00 from coronavirus
SARS-CoV-2 (SCV2) has posed significant global challenges, necessitating improved immunization strategies to enhance protection and mitigate disease severity. Combining Bacille Calmette-Guérin (BCG) with SCV2 vaccine shows potential due ...

» Risk of Guillain-Barre syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A multinational self-controlled case series study
28/05/25 20:00 from sars-cov-2
CONCLUSION: In this large multinational study, we found increased risks of GBS within 42 days after Vaxzevria/Covishield vaccination or SARS-CoV-2 infection, and decreased risks after receiving Comirnaty/Tozinameran or CoronaVac/Sinovac ...

» Serum proteomic approach to identifying differentially expressed proteins in effusive feline infectious peritonitis
28/05/25 20:00 from coronavirus
Feline infectious peritonitis (FIP) is a lethal, viral-induced immune-mediated disease that remains a challenge for diagnosis and treatment in cats. Proteomic profiling, which analyzes the protein content of biological samples, offers th...

» Whole-Body [¹⁸F]DPA-714 Kinetic Assessment Using PET/CT Scanner with Long Axial Field of View
28/05/25 20:00 from coronavirus
Multisystemic inflammation might be a key pathophysiologic mechanism in post-coronavirus disease 2019 (post-COVID) syndrome. N,N-diethyl-2-(2-(4-(2-fluoroethoxy)phenyl)5,7dimethylpyrazolo[1,5a] pyrimidin-3-yl)acetamide ([^(18)F]DPA-714),...

» Drug treatments for mild or moderate covid-19: systematic review and network meta-analysis
28/05/25 20:00 from coronavirus
CONCLUSION: Nirmatrelvir-ritonavir and remdesivir probably reduce admission to hospital, and systemic corticosteroids and molnupiravir may reduce admission to hospital. Several medications including systemic corticosteroids and molnupira...

» Mechanism and biological significance of erythrocyte homoaggregation (rouleaux formation): temperature-dependent entropic liberation of water from cells and macromolecules
28/05/25 20:00 from coronavirus
In the pre-antibiotic era, infections were usually more frequent and serious than today. Robin Fåhraeus (1888-1958) examined the erythrocyte sedimentation rate (ESR) test for infections, which was normally carried out in vitro with fresh...

» Unravelling the mechanism of action of Huashibaidu formula volatile metabolome for the treatment of COVID-19 and its mutants from the perspectives of network pharmacology and molecular docking
28/05/25 20:00 from coronavirus
CONCLUSIONS: This study revealed that the HSBD formula not only had a therapeutic effect on the initial SARS-CoV-2, but also had a restraining effect on the virus subtypes. This article gives a basic theory for the treatment of COVID-19 ...

» Tipranavir analogs as antiviral agents: Design, synthesis, in vitro, and in silico study of new SARS-CoV-2 main protease inhibitors
28/05/25 20:00 from coronavirus
The current study aims at developing non-peptidic new antiviral hits against main protease (M^(pro)) of SARS-COV2 using the non-peptidic M^(pro) inhibitor tipranavir (TPV) as a starting point. In vitro protease inhibition assay of the ta...

» Xuanfei Baidu Formula confers protection against viral pneumonia by modulating CD8⁺ T cell proliferation via MAPK signalling pathway
28/05/25 20:00 from coronavirus
CONCLUSION AND IMPLICATIONS: In conclusion, we found that XFBD regulates CD8^(+) T cell proliferation through the MAPK signaling pathway, thereby combating viral infection, which helps explain the theory and scientific principle of drug ...

» Clinical Outcomes in Children <5 Years of Age Hospitalized for Respiratory Syncytial Virus, COVID-19 or Influenza in the United States
28/05/25 20:00 from coronavirus
CONCLUSION: Viral respiratory diseases cause a significant burden of illness in hospitalized children <5 years of age. Compared with COVID-19 and influenza, RSV had a significantly higher risk of nearly all inhospital outcomes examined. ...

» Update on the Epidemiology of Middle East Respiratory Syndrome Coronavirus - Worldwide, 2017-2023
28/05/25 20:00 from Covid-19 origins
Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus transmitted sporadically from camels to humans. Most reported human Middle East respiratory syndrome (MERS) cases have occurred in or near the Arabian Peninsula....

» Update on the Epidemiology of Middle East Respiratory Syndrome Coronavirus - Worldwide, 2017-2023
28/05/25 20:00 from Coronavirus origins
Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus transmitted sporadically from camels to humans. Most reported human Middle East respiratory syndrome (MERS) cases have occurred in or near the Arabian Peninsula....

» Changes and continuities in undergraduate nursing education during and after COVID-19: a European comparative study from the perspective of health science
28/05/25 20:00 from coronavirus
CONCLUSIONS: The COVID-19 pandemic has widened the gap between university-educated nurses and the clinical setting, i.e. between theory and practise, underlining the importance of HSS in nursing education. Rebuilding strong partnerships ...

» ACE2, a therapeutic target of COVID-19, needs to be treated with caution
28/05/25 20:00 from sars-cov-2 spike protein
Angiotensin-converting enzyme 2 (ACE2) has garnered significant attention for its crucial role in infection by both SARS-CoV and SARS-CoV-2. Consequently, it has emerged as a potential therapeutic target for treatment of COVID-19. It is ...

» COVID-19 disease severity in language minorities in Finland: an observational population-based register study
28/05/25 20:00 from coronavirus
CONCLUSIONS: CRP and leukocyte count were the most reliable indicators of more severe COVID-19 disease presentation and ICU admission. Although those with a foreign first language were overrepresented in COVID-19 related hospitalizations...

» Adolescents Caught Between the Temptation and the Habit of Smoking
28/05/25 20:00 from Covid-19 origins
CONCLUSIONS: Tobacco consumption habits did not seem to be influenced by the new situation created by the COVID-19 pandemic. Regardless of gender, place of origin (rural or urban), or geographical region, the age at which the temptation ...

» Managing withdrawals and exclusions of study participants in COVID-19-research by NUKLEUS
28/05/25 20:00 from coronavirus
CONCLUSIONS: This manuscript is to the author's knowledge one of the first article related to withdrawals within COVID-19-studies (NAPKON). The processes serve as 'best practice' examples for planning and establishing withdrawal processe...

» Technostress Among Older Workers: A Central European Perspective
28/05/25 20:00 from Covid-19 origins
INTRODUCTION: This study explores the impact of two major labor market phenomena-the aging workforce and digitalization, which have global significance. The COVID-19 pandemic accelerated the adoption of digital technologies, resulting in...

» Kawasaki disease in the pre- and post-COVID-19 era: shifts in patterns and outcomes from a multi-center study
28/05/25 20:00 from SARS-CoV-2 and Sars-Cov comparisons
CONCLUSIONS: Our study highlights shifts in the patterns of KD in the post-COVID-19 era. We observed a higher prevalence of incomplete KD cases over the 3 years following the pandemic.

» Did COVID-19 surveillance system sensitivity change after Omicron? a retrospective observational study in England
28/05/25 20:00 from coronavirus
CONCLUSIONS: From September 2021 to June 2022, complementary SS generally reflected case rises and falls. Ascertainment was highest in the Delta-dominant period but no complementary tracker was highly stable. Factors other than which var...

» Application of a high-resolution melt assay for monitoring SARS-CoV-2 variants in Burkina Faso and Kenya
28/05/25 20:00 from SARS-CoV-2 and Sars-Cov comparisons
The rapid emergence and global dissemination of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) highlighted a need for robust, adaptable surveillance systems. However, financial and infrastructure requirements for whole-geno...

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